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Amy Nguyen
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Decks in this class (27)
EXAM 1 - lecture 1: intro
What are the two main components ...,
What is medicial chemistry,
Why are excipients needed
9
cards
EXAM 1 - lecture 2: early stage drug discovery
What best describes the field of ...,
What is usually the first step in...,
How do pharmaceutical companies c...
12
cards
EXAM 1 - Physiochemical Properties of Drug Molecules
Describe the scaffold model,
3d structure is controlled by what,
Which of the following hybridizat...
35
cards
EXAM 1 - Properties of Drug: Target Interactions
What is kon and koff,
Kd ______,
As kd becomes smaller what happen...
19
cards
EXAM 2 - Functional Groups in Drug Molecules (part 1)
What is the significance of the f...,
What factors may functional group...,
What is a pharmacophore
35
cards
EXAM 2 - Functional Groups in Drug Molecules (part 2)
Describe amineskey interactions r...,
Why are anilines less basic than ...,
21
cards
EXAM 2 - Functional Groups in Drug Molecules (part 3)
Classify these amides,
Draw an amide,
Are amides donors or acceptors
32
cards
EXAM 2 - Target Identification and Validation
Explain what target identificatio...,
What does a signal transduction p...
22
cards
EXAM 2 - Principles of Biological Assays & Lead Compound Identification
Describe the difference between i...,
When measuring how active a compo...,
What output does a colorimetric a...
17
cards
EXAM 3 - Principles of Biological Assays & Lead Compound Identification
Define ic50,
What does a high ic50 10 mean ver...,
List the steps to generate ic50 v...
11
cards
EXAM 3 - Structure-Activity Relationships (SAR)
Why are structure activity relati...,
Explain the significance of deter...,
What is it used for how does x ra...
32
cards
EXAM 3 - Chemical Methods for Improving Pharmacokinetics
Explain the importance of optimiz...,
What is the relationship between ...,
Why are bioisoteres used for pk o...
24
cards
EXAM 4 - Organic Synthesis in Drug Development
What is the goal of linear conver...,
What is the goal of combinatorial...
18
cards
EXAM 4 - Organic Synthesis in Drug Development 2
What are good properties of a sca...,
What are good functional groups,
Name what functional groups are n...
18
cards
EXAM 4 - "Late Stage" Drug Development
Why is early stage admet screenin...,
What are the different screens du...,
List the different avenues of dru...
45
cards
EXAM 4 - Gleevec Case Study
What was the first tyrosine kinas...,
What are the majority of kinase i...,
Explain how receptor tyrosine kin...
19
cards
EXAM 4 - Introduction to Clinical Chemistry
Define clinical chemistry,
Define clinical chemistry,
Explain the significance of study...
30
cards
EXAM 5 - Drug Metabolism 1
The properties that enable xenobi...,
Describe the relation between pro...,
Explain why we have drug metaboli...
16
cards
EXAM 5 - Drug Metabolism 2
Explain transition state theory,
How can drugs be used as transiti...,
Describe enzyme conformational se...
26
cards
EXAM 5 - Drug Metabolism 3
What 3 reactions are oxidation ph...,
Describe alcohol dehydrogenase ox...,
Describe aldehyde dehydrogenase o...
26
cards
EXAM 5 - Drug Metabolism 4
Explain what occurs at this step ...,
Explain what occurs during this s...,
Explain what occurs during this s...
22
cards
EXAM 5 - Cofactors for Phase 2 Metabolism 1
All Phase 2 enzymes require cofactors
- this deck goes over the reactions that occur between the enzymes and their cofactors (SPECIFICALLY GLUCURONIDATION)
23
cards
EXAM 5 - Cofactors for Phase 2 Metabolism 2
Describe sulfation sulfonation,
Can sulfonation produce toxic pro...,
Describe
10
cards
EXAM 5 - Phase 3 Elimination
If compounds are hydrophilic pola...,
Explain the reasoning behind phas...,
Explain the significance of the l...
29
cards
EXAM 5 - Biochemical variables that affect drug/xenobiotic metabolism
Explain the following graph,
Explain the relation between reac...,
Describe metabolism when chemical km
24
cards
EXAM 5 - Journal Article
Explain the objective of the jour...,
Explain the objective of the jour...,
Explain the method of the experiment
4
cards
EXAM 5 - Metabolic Drug Interactions
What are the two major types of d...,
What are the two major types of d...,
Explain why p450s are often invol...
10
cards
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PHRX 3002: bioorganic chem
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