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Thomas Monk
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Decks in this class (22)
1. Tumour supressor genes
How do mutations in tsgs contribu...,
What mechanisms exist to control ...,
What s the clinical background of...
12
cards
2. Oncogenes
What is the role of oncogenes,
How do point mutations activate o...,
How does amplification activate o...
8
cards
4. Colorectal Cancer - HNPCC, FAP, MUTYH
What causes hnpcc,
What cancers are caused by hnpcc,
What s the contribution of each g...
25
cards
5. Breast Cancer
What factors complicate the diagn...,
What is the role of brca1 and brca2,
What is the clinical consequence ...
18
cards
6. Neurofibromatosis Type 1 and 2
What is the clinical phenotype of...,
What is the role of nf1,
How is nf1 inherited
8
cards
7. Tuberous Sclerosis
What causes tsc,
What is the role of the tumberous...,
How is the phenotype of tsc chara...
6
cards
8. Other cancer syndromes
What genes are involved in men an...,
What is the clinical phenotype of...,
What is the role of men1
16
cards
9. Examples of cancer pathways
What is the result of mutations i...,
What is the role of the mapk pathway,
What are the 4 major mapk cascade...
17
cards
10. DNA damage response and cancer
Why is dna constantly damaged,
What does mismatch repair recognise,
What genes are involved in mmr
3
cards
12. Pharmacogenetics dose determination and immune response
What are the 3 main reasons for p...,
What are the benefits of pgx,
Which genes contribute to variati...
10
cards
14. Genetics of AML
What type of cells proliferate in...,
How is aml diagnosed,
What are the 2 types of core bind...
27
cards
15. Genetics of CML
What characterises cml,
Clinical symptoms of cml at diagn...,
What characterises cml genetically
19
cards
16. Genetics of ALL
What type of cells accumulate in all,
What are the main types of all wh...,
What are the symptoms of all
27
cards
17. Mature B-cell neoplasms
What is the difference between cl...,
What cells are affected in cll,
Why is karyotyping alone not used...
22
cards
18. Genetics of lymphoma
How is lymphoma characterised,
How is hodgkin s lymphoma charact...,
What is the main risk factor for ...
22
cards
19. Genetics of myelodysplastic syndromes
What 4 factors characterise mds,
Which cell lineages can be involv...,
Why is mds considered pre malignant
21
cards
25. Strategies of MRD monitoring
What is mrd,
What is the purpose of mrd,
How is mrd monitored in aml
17
cards
27. Myeloid proliferative disorders
What type of genes are implicated...,
How are mpns characterised,
What type of cells accumulate in ...
17
cards
Lung cancer
What are the most common oncogeni...,
Why is egfr tested in nsclc,
What is the role of egfr mutation...
17
cards
ctDNA
What is ctdna,
How does ctdna differ from other ...,
What are the advantages of testin...
7
cards
Other solid tumours (CRC, melanoma, ES)
What sample type is,
What cancers is braf commonly mut...,
What is the role of braf
29
cards
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6: Cancer genetics and treatment
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