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Tanveer Bedesha
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Decks in this class (25)
Theme 1 Drug History Lecture 1
How does a beta lactam antibiotic...,
The 4 main parts of how drugs evo...,
First pharmacopeia
21
cards
Theme 1 Lecture 2
Elucidation of morphine structure,
What developments were there,
Gemtuzumab ozogamicin
16
cards
Theme 1 Lecture 3
Case study 1,
Discovery of mefloquine,
Project 523
24
cards
Theme 2 Lecture 4 Brief History of Drug Discovery
Describe the evolution of drug sc...,
Explain the evolution of classica...,
Identify key blockbuster drugs
18
cards
Theme 2 Lecture 5
Types of target and ways of targe...,
Gpcrs,
Rtks
15
cards
Theme 2 Lecture 6
Explain what agonism is,
Do agonists have varied efficacies,
What is receptor reserve and the ...
23
cards
Theme 2 Lecture 7
How do drugs bind to receptors,
Describe kd dissociation constant,
What is the law of mass action
27
cards
Theme 2 Lecture 8
Describe the crispr cas9 system f...,
Genome editing outcomes,
Cxcr4 receptor crucial in cancer
15
cards
Theme 3 Lecture 9
Diseases that have not been found...,
Drug discovery process in steps,
How are chemical starting points ...
18
cards
Theme 3 Lecture 10
Plant drug basd origins digoxin,
First analysis of digoxin,
Morphine meperidine and fentanyl
17
cards
Theme 3 Lecture 11
What are legacy libraries and the...,
What is the difference between di...,
What are drug like properties in ...
13
cards
Theme 3 Lecture 12
In a large library of compounds h...,
In a large library of compounds h...,
What are the considerations regar...
15
cards
Theme 4 Lecture 13
Introduction to hts,
Describe the typical setup of hts,
What are the three main types of hts
27
cards
Theme 4 Lecture 13 Extra Reading
Perm and tox enzymes in vitro not...,
What is histone methylation,
Hmt biochemical assays
11
cards
Theme 4 Lecture 14
Why is it important to identify h...,
What is the significance of using...,
What key parameters are used to e...
18
cards
Theme 4 Lecture 15
What is the role of fragment base...,
How is virtual screening used for...,
What is the significance of bace ...
13
cards
Theme 5 Lecture 16 Optimization of drug targets
Lead optimisation theme 3,
3 activities that they aim to ach...,
This process covers 3 main activi...
19
cards
Theme 5 Lecture 17
What is sar,
Sar studies congeners,
Historical methods of quantifying...
16
cards
Theme 5 lecture 18
Ligand based drug discovery 5ht2c,
Virtual screening,
Comfa comsia
10
cards
Theme 5 Lecture 19
Schering plough cannabinoid recep...,
Pharmacophore model built from ei...,
What was the selected model used
16
cards
Theme 6 Lecture 20
P se ph ph saf ccwhat does lead o...,
Slide 2what is it about lead opti...,
Molecule activitywhere does lead ...
22
cards
Theme 6 Lecture 21
What is the goal of lead optimisa...,
What role do rules and metrics pl...,
How is ligand efficiency le defined
12
cards
Theme 6 Lecture 22
What are the two key factors affe...,
How can poor solubility in compou...,
What indicates high crystal latti...
19
cards
Theme 6 Lecture 23
Acidic and benzenewhat are the ke...,
What did the addition of the new ...,
What was distinct about the selec...
18
cards
Theme 7 Lectures Summarised
Why is it crucial to file a paten...,
What is the duration and purpose ...,
Drafting and filing 6what are the...
25
cards
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