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Tanveer Bedesha
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Decks in this class (25)
Theme 1 Drug History Lecture 1
How does a beta lactam antibiotic...,
The 4 main parts of how drugs evo...,
First pharmacopeia 3
21
cards
Theme 1 Lecture 2
Elucidation of morphine structure 1,
What developments were there 2,
Gemtuzumab ozogamicin 3
16
cards
Theme 1 Lecture 3
Case study 1 1,
Discovery of mefloquine 2,
Project 523 3
24
cards
Theme 2 Lecture 4 Brief History of Drug Discovery
Describe the evolution of drug sc...,
Explain the evolution of classica...,
Identify key blockbuster drugs 3
18
cards
Theme 2 Lecture 5
Types of target and ways of targe...,
Gpcrs examples 2,
Rtks examples 3
15
cards
Theme 2 Lecture 6
Explain what agonism is 1,
Do agonists have varied efficacies 2,
What is receptor reserve and the ...
23
cards
Theme 2 Lecture 7
How do drugs bind to receptors 1,
Describe kd dissociation constant 2,
What is the law of mass action 3
27
cards
Theme 2 Lecture 8
Describe the crispr cas9 system f...,
Genome editing outcomes 2,
Cxcr4 receptor crucial in cancer 3
15
cards
Theme 3 Lecture 9
Diseases that have not been found...,
What are the phases of drug disco...,
How are chemical starting points ...
18
cards
Theme 3 Lecture 10
Plant drug basd origins digoxin 1,
Ephedrine more potent and less to...,
Morphine meperidine and fentanyl 3
17
cards
Theme 3 Lecture 11
What are legacy previous librarie...,
What is the difference between di...,
What is the general concept of li...
13
cards
Theme 3 Lecture 12
Define combinatorial libraries an...,
Explain the concept of a 2 dimens...,
What are the considerations regar...
15
cards
Theme 4 Lecture 13
What is the role of high throughp...,
Describe the typical setup of hts 2,
What are the three main types of ...
27
cards
Theme 4 Lecture 13 Extra Reading
Cell based vs biochemical assay 1,
Express therap what is histone me...,
Sel pot kin what are hmt biochemi...
11
cards
Theme 4 Lecture 14
Why is it important to identify h...,
What is the significance of using...,
What key parameters are used to e...
18
cards
Theme 4 Lecture 15
What is the role of fragment base...,
How is virtual screening used for...,
What is the significance of bace ...
13
cards
Theme 5 Lecture 16 Optimization of drug targets
Lead optimisation theme 3 1,
Lo process and identification of ...,
This process covers 3 main activi...
19
cards
Theme 5 Lecture 17
What is sar 1,
Sar studies congeners 2,
Historical methods of quantifying...
16
cards
Theme 5 lecture 18
Ligand based drug discovery 1,
Virtual screening 2,
Comfa comsia 3
10
cards
Theme 5 Lecture 19
Schering plough cannabinoid recep...,
Pharmacophore model built from ei...,
What was the selected model used 3
16
cards
Theme 6 Lecture 20
What does lead optimisation invol...,
What is it about lead optimisatio...,
Where does lead optimisation focus 3
22
cards
Theme 6 Lecture 21
What is the goal of lead optimisa...,
What role do rules and metrics pl...,
How is ligand efficiency le defin...
12
cards
Theme 6 Lecture 22
What are the two key factors affe...,
How can poor solubility in compou...,
What indicates high crystal latti...
19
cards
Theme 6 Lecture 23
What are the key steps in the lea...,
What did the addition of the new ...,
What was distinct about the selec...
18
cards
Theme 7 Lectures Summarised
Why is it crucial to file a paten...,
What are the key components of a ...,
What are the estimated costs of p...
25
cards
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