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Becca Wilson
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Decks in this class (21)
L14 - Antiviral drug discovery
Intended Learning Outcomes
• Being able to explain the fundamental principles
of antiviral drug discovery and validation.
• Knowing the main antiviral drug discovery
pipelines.
• Being able to describe key antiviral mechanisms.
• Being familiar with major breakthroughs in
antiviral treatment and their impact on public
health.
• Being aware of challenges in antiviral treatment,
such as drug resistance, toxicity, and effective
92
cards
L13 - RNAi and viruses
Intended Learning Outcomes
• Describe the concept of RNA-interference.
• Describe the roles of the endonucleases DICER and Argonaute-2.
• Explain how the RISC (RNA-induced Silencing Complex) complex inhibits virus replication in plants and insects.
• Explain the role of viral encoded suppressors of RNAi (VSRs) in viral infection.
• Discuss the role of RNAi in the regulation and inhibition of virus replication in mammalian cells.
80
cards
L12 - RNA virus replication structure
What is a model rna virus used to...,
Why do viruses induce structural ...,
What cellular components are invo...
95
cards
L11 - Bacterial exploitation of host cytoskeleton and intracellular trafficking
What are the three principal comp...,
Which protein is the main constit...,
What is the approximate diameter ...
122
cards
L10 - How Bacteria Evade the Human Immune System to Cause Disease
Intended Learning Outcomes (ILOs)
•Understanding of ‘evolutionary arms race’ between pathogen and host
•Outline of the human immune system
•Specific mechanisms of bacterial immune evasion
89
cards
L7 - Virus uncoating
What is the role of the ubiquitin...,
How do microtubules contribute to...,
Which motor proteins facilitate m...
51
cards
L6 - Genetic manipulation of viruses
LO:
- Appreciate the qualities required of hypothetical “ideal vector”
- Know the four principle gene therapy vectors
- Understand the principles behind the most widely used vector -adenovirus
- Know the details of how this virus is modified to make gene therapy/vaccine vectors
- Understand the principle problems and advantages of this vector system
- Have an overview of how the ChAdOx1 nCoV-19 was made and its transcription profile
79
cards
L1 – Variation of Bacterial Surface Structures
Why do bacteria modulate their su...,
In what way does host immune pres...,
What is antigenic variation and h...
45
cards
L5 - Viral Entry
What is the significance of virus...,
How do viruses achieve high local...,
What are the two general pathways...
59
cards
L4 - Viral structure
What is icosahedral symmetry and ...,
What characterises helical virus ...,
Why is understanding virus symmet...
57
cards
L3 – Bacterial Recombineering, Virulence Factor Identification and Characterisation
What natural process is recombine...,
What are key steps in constructin...,
What is a knock in strategy in th...
58
cards
L2 – How Bacterial Toxins Contribute to Disease and Dissemination
What are bacterial toxins and why...,
What are the two broad classifica...,
How does an endotoxin differ from...
151
cards
L15 - Bacterial protein secretion and assembly of surface structures
What is the primary structural di...,
What are the two major secretion ...,
How does the sec pathway function 3
79
cards
L16 - How will genome sequencing help us control bacterial infections
What is attachment 1,
What are the four attachment styl...,
Describe the secure attachment st...
105
cards
L17 - Whole Genome Sequencing (WGS) and Bacterial Diagnostics
What are first generation vaccines 1,
Give an example of an inactivated...,
What are second generation vaccin...
111
cards
L18 - GWAS and Bacterial Research
What does gwas stand for 1,
What is the purpose of gwas 2,
What type of traits does gwas ide...
74
cards
L8 - Transcriptomics
What are the two main omics techn...,
What does rna seq analyze 2,
What is proteomics 3
98
cards
L19 - Molecular approaches to bacterial vaccine design; problems and solutions
What is the primary focus of vacc...,
Why are vaccines essential for co...,
Which infections are considered u...
77
cards
L9 - Proteomics
What is the purpose of running a ...,
What role does in gel digestion p...,
Where does trypsin specifically c...
55
cards
Section A (Viruses) Practice exam questions
Discuss the role of rna interfere...,
Explain the stepwise process of g...,
Evaluate how structural biology h...
20
cards
Section B (Bacteria): Practice exam questions
Compare how shigella and listeria...,
Discuss the mechanisms by which p...,
Evaluate how genome wide associat...
20
cards
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Frontiers in Infectious diseases
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