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Aefre Mak
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Decks in this class (11)
L1: What is pharmacology?
intro to the module
38
cards
L2: Sources of drugs & their nature
Learning Objectives:
• List some key points in the history of the pharmaceutical industry
• List the main sources of drugs, giving examples from each source
• Describe the key stages in the drug discovery process
• Explain what is meant by the term “structure-activity relationship” and why it is important in drug development
List the four phases of clinical trials and explain the main purpose of each phase
35
cards
L3: Concentration Response Relationship
• Draw typical “concentration vs response” and “log concentration vs response” curves with appropriately labelled axes
• List some common responses to drugs and explain how they are measured
• Distinguish between in vitro, in vivo and ex vivo measurements
• Explain the term “EC50” and how it is measured
• Distinguish between the terms “potency”, “potency ratio” and “relative potency”
Explain the term “Therapeutic Index” and how it is measured
27
cards
L4: Drug Action at Receptors
Learning Objectives:
• Explain the role of receptors in cell signalling
• Define the terms “specificity”, “affinity” and “efficacy”
• List the main forms of antagonism produced by drugs
• Describe the differences between the actions of full agonists, partial agonists and competitive antagonists on receptors
- Describe the effect of a reversible competitive antagonist on the log concentration vs response curve for an agonist
42
cards
L5: Measuring of drug action
What are radioligand binding assays,
First step of measuring affinity,
Second step of measuring affinity
22
cards
L6: Basic tissue types & systems
Define tissues,
Define organs,
3
cards
L7: Neurotransmitter identification & proof of function
4 usual steps towards establishin...,
Define piloerection,
Define bladder relaxation
12
cards
L8: drugs affecting neuromuscular junction
How many processes can drug affec...,
What processes pre synaptifcally ...,
What processes post synaptically ...
35
cards
L9: Drugs affecting the PNS
What is the autonomic ns involved in,
Subdivisions of the autonomic ns,
Function of sympathetic ns
22
cards
L10: Drugs affecting SYM NS 1
3 branches in the peripheral nerv...,
What does sympathetic ns prepare ...,
How does efferent nerves of the s...
35
cards
L11: Drugs affecting SNS 2
Describe the effects of the activ...,
How,
Define adrenoceptors
12
cards
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Fundamentals of Pharmacology
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