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Mehmet Hazirci
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Decks in this class (13)
Genetics and Genomics
Differentiate between genetics and genomics and assess key historical events in their development
Understand the relationship between genotype and phenotype and forward and reverse genetics
Differentiate the terms "genome", "transcriptome", and "proteome"
Appreciate the influence of environment and epigenetics on phenotype
Differentiate acquired vs inherited and sample vs complex genetic diseases
20
cards
Cytogenetics of Nuclear Chromosomes
Recall the changes in number, position, and condensation state of nuclear chromosomes during mitotic and meiotic cell cycles
Explain the relationship between Mendelian inheritance and the behaviour of meiotic chromosomes and gametes
Understand and interpret basic pedigree analyses and karyotypes
7
cards
Biochemical Features of Nuclear Chromosomes
Describe some key components that determine their structure & function
8
cards
The Mitochondrial Chromosome
Differentiate between the proeprties and significance of nuclear and mitochondrial chromosomes
6
cards
DNA Sequence Organisation of the Human Genome
Explain how DNA was shown to be the genetic material
Describe some DNA analysis techniques
Recognise the key DNA sequence features in the human genome including their arrangement and significance
28
cards
Genetic Variation Between Species
Identify features shared between the human genome and genomes of model organisms & pathogens
Infer evolutionary relationships between organisms based on genome sequence comparison
Describe the mechanism by which genomes can change, and how it can result in evolution
Describe the major databases cataloguing human genetic variation & be able to find relative allele frequencies of polymorphic sites
Appreciate the importance of comparative genomics in modern medicine
2
cards
Mechanisms of Creating Genetic Diversity
What does deleterious mean,
Describe chromosomal recombinatio...,
Describe the process of chromosom...
10
cards
Mapping the Genome
Explain the principles of linkage analyses
Describe the difficulties of linkage analyses in humans and how they're addressed
Demonstrate an understanding of key physical mapping techniques
Explain how physical & genetic mapping are used together to identify functional genome sequences
Describe the principles & uses of population based gene mapping methods
19
cards
Replicating the Genome
Review the basic molecular mechanism of DNA replication
Explain why cell cycle control is essential for genome maintenance
Describe replication origins & their control
Explain how cyclin dependent kinases control S and M-phases
Describe the topological problems of DNA replication & their solutions
Describe the problem of DNA end-replication & how telomerase acts
18
cards
Expressing the Genome
Describe the anatomy of a gene,
Describe what is meant by gene ex...,
How can we measure gene expression
29
cards
Protecting the Genome
Outline the causes of dna damage,
Explain how ros can damage the dn...,
Explain the effect of different t...
36
cards
Engineering the Genome
What is bacterial transformation ...,
Explain the concept of competency...,
Detail the process of how natural...
30
cards
New and Future Developments
What are the current methods for ...,
What are the benefits of next gen...,
Describe the benefits of single c...
24
cards
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Genetics and Genomics
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