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Unknown User
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Decks in this class (8)
The biology of muscle damage and remodelling
-Define exercise-induced muscle ‘damage’ (EIMD)
-Explain the characteristics and temporality of muscle damage/repair
-Discuss the mechanisms that co-ordinate muscle remodelling following acute damage – Including classical theories and novel hypotheses
-Place evidence from multiple model organisms into a physiological context of human muscle repair
20
cards
Metabolic and molecular basis for adaptation to resistance-type exercise
-What is resistance (type) exercise, and what are the major adaptations it elicits? Why is it critical for us to understand how resistance training leads to adaptation?
-What are the responses to a single bout of resistance-type exercise at different levels of physiology:
o Physiological (protein metabolism)
o Cellular (cellular protein turnover and role of satellite cells)
o Molecular (anabolic signalling pathways)
-How do these acute responses accumulate into adaptation?
17
cards
Metabolic and molecular basis for adaptation to endurance-type exercise
-What is endurance (type) exercise, and what are the major adaptations it elicits? Why is it critical for us to understand how endurance training leads to adaptation?
-What are the responses to endurance-type exercise at different levels of physiology:
o Physiological (e.g. aerobic capacity and cardiac output)
o Cellular (e.g. cardiac remodelling, angiogenesis, mitochondrial biogenesis)
o Molecular (e.g. cellular signalling pathways regulating the above events)
-How do these acute responses
15
cards
Physiological and molecular mechanisms underlying the adaptation to physical inactivity
-What do we mean by physical inactivity and ‘disuse’ and what are the major adaptations it elicits?
-Why is it critical for us to understand how inactivity results in deconditioning?
-What factors influence the rate of disuse induced deconditioning?
-What are the responses to physical inactivity or disuse at different levels of physiology:
o Physiological
o Cellular
o Molecular
18
cards
Modern molecular biology and the prediction of human physiology, disease and performance
-Discuss the principles and application of Western blot and immunofluorescence analysis
-Explain the concept and principles underlying ‘omics’ analyses
-Understand how ‘omic’ approaches can facilitate understanding of adaptation to activity – Including examples from recent literature
23
cards
Sarcopenia: age-related declines in skeletal muscle
-Background to muscle mass maintenance:
o Describe why muscle is important
o Explain how muscle mass is regulated in healthy individuals and how we can measure this
-Apply to sarcopenia:
o Describe sarcopenia and its clinical manifestations
o Discuss the molecular and metabolic alterations that underpin sarcopenia
o Consider how what we know from molecular studies inform interventional approaches
-Emphasis on main stimuli of muscle growth:
o Exercise
o Nutrients
13
cards
Mitochondrial function adaptation to physical activity
Where does energy come from,
What is atp,
Why is energy required
20
cards
Vascular contribution to muscular health
-To understand the important role of blood flow in the circulatory system
-To appreciate the relationship between blood flow, mean arterial pressure, cardiac output and total peripheral resistance
-To understand the factors that govern total peripheral resistance via Poiseuille's law
-To describe distinct vessel characteristics and functions across the cardiovascular system
-To describe the dynamics and distribution of blood flow within body tissues at rest and in response to exercise, and t
23
cards
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Integrated Physiology and Adaptation To Physical (in) Activity
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