Quiz 3

- Identify common types of pain - Provide appropriate analgesic product and dosage recommendations - Know symptoms that require escalation of care

Explain the IESC framework for evaluating a patient’s drug-related needs List the three components of a DTP (drug-problem/medical condition relationship). Differentiate between the 7 DTPs. Review the translation of a patient's drug-related needs into an assessment of drug therapy problems (DTPs). Evaluate a patient case in order to identify DTPs. Properly document DTPs (including DTP category and cause, as well as drug-problem/medical condition-relationship) in the “assessment” portion of

Identify key structural motifs that determine O2 affinity and ligand binding. Articulate the mechanism of O2 binding to myoglobin and hemoglobin. Explain the biomolecular basis of differences in Mb and Hb function in O2 transport.

Describe the molecular basis of O2 transfer from parental hemoglobin to fetal hemoglobin Articulate differences in the effect of allosteric effectors in regulating O2 affinity to fetal hemoglobin. Link changes in affinity to primary sequence differences in parental hemoglobin and fetal hemoglobin

Describe the major market segments in the pharmaceutical market. Compare & contrast hallmarks of economic competition with market conditions for brand-name medications. Differentiate among the various stakeholder perspectives on the pricing of pharmaceutical products. Explain the major components involved in prescription drug reimbursement. Explain the major components involved in prescription drug use and expenditures.

Know the principal effects of the endogenous eicosanoids. Understand signaling pathways and mechanism of action for the endogenous eicosanoids. Know the targets and principal effects of the agents that mimic endogenous eicosanoids or alter their impact. Predict side/adverse effects of selected endogenous eicosanoids, synthetic eicosanoid derivatives, and eicosanoid inhibitors. Specific diseases and medical settings can benefit from eicosanoid-related pharmacology

Identify NSAIDs and know their mechanism of action Understand the side effects Understand the role of prostaglandins in health and disease

Explain medication errors caused by common abbreviations. Calculate doses, including using mg/kg and BSA methods Calculate concentration, ratio strength

Apply what you have learned so far this semester to a patient case. Identify and document therapeutic alternatives to resolve the DTP.

Discuss the approach to selecting resources to respond to determining drug therapy problems Utilize selected resources to respond to determine drug therapy problems Discuss the process and importance of clinical reasoning and how it synergizes with EBP

Explain the molecular basis to change in O2 affinity of Hb as a function of blood pH. Explain the molecular basis to differential binding of carbon monoxide and O2 to Hb. Describe the effect of negative allosteric effectors on Hb O2 transport and release in active muscle tissue (at the molecular level).