Stage 2 Basic Pharmacology

General principles and targets for drug action Describe the targets of drug action Describe the receptor-effector mechanisms activated by agonists Define pharmacodynamics and pharmacokinetics Discuss the sources of drugs Explain how drugs interact with their targets Define the four main targets for drug action

Explain how drugs act at their targets Define the terms agonist and antagonist Explain the concept of receptor subtypes Describe the four main types of receptor

To assist you in acquiring the knowledge & understanding to: Compare the potency and efficacy of drugs on the basis of their dose-response curves Determine whether an antagonist is competitive or non-competitive (irreversible) on the basis of its effect on the dose-response curve of the agonist Define graded and quantal dose-response curves Discuss affinity and receptor-binding curves Compare potency and efficacy from dose-response curves Explain the concept of full, partial and inverse agonist

a) routes of adminestration b) + and - c) bioavailability and distribution d) pKa and pH, movement e) distribution of drug f) volume of distribution

Hepatoenteric recirculation 2) phase 1 and 2 metabolism 3) excretion