PET is nearly universally positive at diagnosis inDLBCL, FL and nodal MZL, but less sensitive for _____.
Extranodal MZL
Latge population based studies have demonstrated a strong associatiob between seropositivity for HCV abd development of B-cell lymphoma. The prevalence was increased among ____ and ____
DLBCL
MZL
Direct acting antiviral agents (DAA) approved for tx in combination with PEG interferon and ribavirin of pxs with HCV genotype 1 infection
Telaprevir
Boceprevir
Used for pxs with significant renal dysfunction receiving high dose methotrexate
Glucarpidase
Components of FLIPI-2 (5)
Age
Hemoglobin
Longest diameter of largest involved lymph nide
B2 microglubin
Bone marrow involvement
Gelf Criteria (7)
-clinically useful to guide initiation of tx in Follicular lymphoma
- Involvement of >/= 3 nodal sites, each with a diameter of >/= 3 cm
- Any nodal or extranodal tumor mass woth a diameter of >/= 7cm
- B symptoms
- Splenimegaly
- Pleural effusion or peritoneal ascites
- Cytopenia (leukocytes <1 x 10^9/Lor platelets <100)
- Leukemia (>5 x 10^9/L)
Has a critical role in the pathogenesis of EMZL of stomach. It’s eradication can lead to tunor remisssion
H.pylori
Preferred regimen for FL high tumor burden
- BR or OR
- CHOP + O or R
- CVP + O or R
- Lenalidomide + rituximab
Definition of Laboratory TLS
25% increase in levels of serum uric acid, potassium, phosphorus
25% decrease in calcium levels
IPI (5)
- Age > 60yrs
- Serum LDH > normal
- PS 2-4
- Stage III or IV
- Extranodal involvement > 1 site
Low 0-1
Low-int 2
High - int 3
High 4 or 5
CNS-IPI
Age > 60yrs
LDH > Normal
PS> 1
Stage III or I
Extranodal involvement or > 1 siye
Kidney or adrenal involvement
Low 0-1
Int 2-3
High 4-6 or kidney or adrenal involvement
