Name the 3 Limb axes
Anterior (towards head) - Posterior (towards feet)
Proximal (towards centre body) - Distal (away from centre body)
Dorsal (front) - Ventral (back)
Where does initial outgrowth occur?
the flank of mesoderm
What is key for initial outgrowth?
FGF signal
How does FGF travel and what does it bind to?
travels through the mesenchyme to bind to receptor proteins
Name the axis on which the initial outgrowth occurs
Proximal - Distal
What pattern does the mesoderm determine and by what signalling is it orchestrated by?
determines cell death pattern by BMP signalling