11 - Immunodeficiency

Question 1

Types of secondary immunodeficiency

Answer 1

Stress, surgery, burns, malnutrition, cancer, drugs, irradiation ,AIDS, measles, TB

Question 2

Types of primary immunodeficiency

Answer 2

Very rare

Well studied

Question 3

Chronic granulomatous disease (CGD)

Answer 3

Osteomyelitis
Pneumonia
Swollen lymph nodes
Gingivitis
Non-malignant granulomas
Inflammatory bowel disease

Question 4

XL agammaglobulinaemia

Answer 4

defect in B cells
Degrees of loss of antibody secretion
Leads to recurrent bacterial infection
Diagnosed at around 1-2 years since maternal IgG protects

Question 5

what does SCID stand for?

Answer 5

Severe combined immunodeficiency syndromes

Question 6

Defects in T cells

Answer 6

usually more dramatic since B cells also need T cell help

Symptoms are recurrent infection with opportunistic infections