13- GI I

Question 1

what does the parietal cell secrete?

Answer 1

• HCL (prtn digestion, sterilization, nutrient absorption)

- Intrinsic Factor (vitamin B12 absorption)

Question 2

what does the chief cell secret?

Answer 2

Pepsinogen (prtn digestion)

Question 3

what does the superficial epithelial cell secrete?

Answer 3

Mucus and bicarbonate (gastroprotection)

Question 4

what does the ECL secrete?

Answer 4

Histamine (promote HCl secretion)

Question 5

what does the G cell secrete?

Answer 5

gastrin (promote HCl secretion)

Question 6

What is the role of Ach in stomach mucosa?

Answer 6

• promote mucus secretion
• promote bicarb secretion
• promote HCl secretion

Question 7

what do D cells secrete?

Answer 7

Somatostatin (suppress HCl secretion)

Question 8

3 roles of prostaglandins

Answer 8

1. mucus and bicarb secretion
2. suppress HCL secretion
3. Increased gastric blood flow

Question 9

2 most common causes ulcers in US

Answer 9

NSAIDS and h. pylori infection

Question 10

why does h. pylori cause infection?

Answer 10

inhibits cyclooxygenase which thereby blocks prostaglandin formation

Question 11

common adverse effects of anatacids

Answer 11

reduced drug bioavailability due to pH changes

enteric infection risk increase (also due to pH changes)

Question 12

fastest antacid

Answer 12

sodium bicarb

Question 13

adverse effects sodium bicarb

Answer 13

• metabolic alkalosis
• excessive NaCl absorption
• gas/bloating

Question 14

specific adverse effects calcium carb

Answer 14

• acid rebound

- gas/bloating

Question 15

specific adverse effects magnesium hydroxide

Answer 15

osmotic diarrhea

Question 16

specific adverse effects aluminimun hydroxide

Answer 16

constipation

Question 17

common adverse effect of H2 receptor antagonists

Answer 17

headache

Question 18

specific adverse effects cimetidine

Answer 18

• CNS (confusion , hallucinations, agitation)
• Endocrine (could lead to gynecomatia)
• inhbit CYP metabolism (drug-drug interactions)

Question 19

key role for prostaglandins

Answer 19

• mucus and bicarb secretion
• suppression ofHCL secretion
• increasedd gastsric blood flow

Question 20

prostaglandin analogue acid-peptic disease treatment option

Answer 20

misoprostol

Question 21

what agent would you use to treat acid-peptic disease and the patient is hospitalized?

Answer 21

sucralfate

Question 22

standard of treatment for h. pylori ulcers

Answer 22

"new triple therapy"
PPI
clarithromycin
amoxicillin
metronidazole