2. Path Markers - Path

Question 1

Pathologic Markers for Prostate Cancer

Answer 1

• PSA

- Prostatic acid phosphatase

Question 2

PSA

Answer 2

Prostate specific antigen

• Used to screen for prostate carcinoma
• Can also be elevated in BPH and Prostatitis

Question 3

Prostatic Acid Phosphatase

Answer 3

• Marker of prostate carcinoma

Question 4

CEA

Answer 4

Carcinoenbyonic antigen

• Very non-specific
• Most colorectal and pancreatic cancers
• Some gastric, breast, and thyroid medullay carcinomas

Question 5

Pathologic Marker for Non-Seminomatous Germ Cell Testicular Tumors (Yolk Sac Tumor)

Answer 5

a-fetoprotein

Question 6

a-fetoprotein

Answer 6

• Marker for Non-Seminomatous Germ Cell Testicular Tumors (Yolk Sac Tumor)
• Low levels seen in Down’s syndrome
• High levels seen in neural tube defects

Question 7

Pathologic Marker for Hydatidiform Moles

Answer 7

b-HCG

- Levels also increased in Choriocarcinoma and Gestational trophoblastic tumor

Question 8

b-HCG

Answer 8

Human Chorionic Gonadotropin
- Marker for Hydatidiform moles, Choriocarcinomas, and Gestational trophoblastic tumors

“HCG = Hydatidiform moles, Choriocarcinoma, Gestational trophoblastic tumor”

Question 9

Pathologic Marker for Choriocarcinoma

Answer 9

b-HCG

- Levels also increased in Hydatidiform moles and Gestational trophoblastic tumor

Question 10

Pathologic Marker for Gestational Trophoblastic Tumor

Answer 10

b-HCG

- Levels also increased in Choriocarcinoma and Hydatidiform moles

Question 11

Pathologic Marker for Ovarian Cancer

Answer 11

CA-125

- Levels also increased in malignant epithelial tumor

Question 12

Pathologic Marker for Malignant Epithelial Tumors

Answer 12

CA-125

- Levels also increased in Ovarian cancer

Question 13

CA-125

Answer 13

Marker for Ovarian cancer or Malignant epithelial tumor

Question 14

Pathologic Marker for Melanoma

Answer 14

S-100

- Levels also increased in Neural tumors and Schwannomas

Question 15

Pathologic Marker for Neural Tumors

Answer 15

S-100

- Levels also increased in Melanoma and Schwannomas

Question 16

Pathologic Marker for Schwannoma

Answer 16

S-100

- Levels also increased in Neural tumors and Melanoma

Question 17

S-100

Answer 17

Marker for:

• Melanoma
• Neural tumors
• Schwannomas

Question 18

Pathologic Marker for Bone Metastases

Answer 18

Alkaline Phosphatase

- Levels also elevated in Obstructive biliary disease and Paget’s of the bone

Question 19

Pathologic Marker for Obstructive Biliary Disease

Answer 19

Alkaline Phosphatase

- Levels also elevated in Bone metastases and Paget’s of the bone

Question 20

Pathologic Marker for Paget’s of the Bone

Answer 20

Alkaline Phosphatase

- Levels also elevated in Obstructive biliary disease and Bone Metastases

Question 21

Alkaline Phosphatase

Answer 21

Marker for:

• Metastases to the bone
• Obstructive biliary disease
• Paget’s of the bone

Question 22

Pathologic Marker for Neuroblastoma

Answer 22

Bombesin

- Levels also elevated in lung and gastric cancer

Question 23

Pathologic Marker for Lung Cancer

Answer 23

Bombesin

- Levels also elevated in Neuroblastoma and Gastric cancer

Question 24

Pathologic Marker for Gastric Cancer

Answer 24

Bombesin

- Levels also elevated in Neuroblastoma and Lung cancer

Question 25

Bombesin

Answer 25

Marker for: - Neuroblastoma - Gastric Cancer - Lung Cancer

Question 26

Pathologic Marker for Hairy Cell Leukemia

Answer 26

TRAP - Tartrate-resistant acid phosphatase "TRAP the HAIRY animal"

Question 27

TRAP

Answer 27

- Tartrate-resistant acid phosphatase | - A marker for Hairy cell leukemia - a B cell neoplasm

Question 28

Pathologic Marker for Pancreatic Adenocarcinoma

Answer 28

CA-19-9

Question 29

CA-19-9

Answer 29

Marker for Pancreatic adenocarcinoma

Question 30

Pathologic Marker for Thyroid Medullary Carcinoma

Answer 30

Calcitonin

Question 31

High Calcitonin Levels

Answer 31

Marker for Thyroid Medullary Carcinoma

Question 32

Psammoma Bodies

Answer 32

Marker for: - Papillary thyroid adenocarcinoma - Serous papillary cystadenocarcinoma of the ovary - Meningioma - Malignant mesothelioma "PSaMMoma = Papilly thyroid adenocarcinoma, ovarian Serous papillary cystadenocarcinoma, Meningioma, Mesothelioma"

Question 33

Pathologic Marker for Papillary Thyroid Adenocarcinoma

Answer 33

Psammoma Body - Also seen in Ovarian serous cystadenocarcinoma, Meningioma, Mesothelioma "PSaMMoma = Papilly thyroid adenocarcinoma, ovarian Serous papillary cystadenocarcinoma, Meningioma, Mesothelioma"

Question 34

Pathologic Marker for Ovarian Serous Cystadenocarcinoma

Answer 34

Psammoma Body - Also seen in Papillary thyroid adenocarcinoma, Meningioma, Mesothelioma "PSaMMoma = Papilly thyroid adenocarcinoma, ovarian Serous papillary cystadenocarcinoma, Meningioma, Mesothelioma"

Question 35

Pathologic Marker for Meningiomas

Answer 35

Psammoma Body - Also seen in Papillary thyroid adenocarcinoma, Ovarian serous cystadenocarcinoma, Mesothelioma "PSaMMoma = Papilly thyroid adenocarcinoma, ovarian Serous papillary cystadenocarcinoma, Meningioma, Mesothelioma"

Question 36

Pathologic Marker for Mesothelioma

Answer 36

Psammoma Body - Also seen in Papillary thyroid adenocarcinoma, Ovarian serous cystadenocarcinoma, Meningioma "PSaMMoma = Papilly thyroid adenocarcinoma, ovarian Serous papillary cystadenocarcinoma, Meningioma, Mesothelioma"