2020

Question 1

labs to order in drug induced SLE

Answer 1

1. anti chromatin ab
2. anti histone ab
3. CBC and CRP

Question 2

SCIG dosing for an average female adult

Answer 2

100 mg/kg/week = 5 grams a week in patient is 50 kg

Question 3

What induces TH1

Answer 3

IL12, and IL27

Question 4

What induces TH2

Answer 4

IL4

Question 5

What is the master regulator of TH1 and TH2

Answer 5

Stat4 and stat6

Question 6

what is the function of TH1 and TH2

Answer 6

1. intracellular defence

2. allergies and anti parasitic

Question 7

cytokines produced by Th1, th2

Answer 7

IFN-y

IL4, 5, 13, 21, 25, 10

Question 8

Describe 3 mechanisms in which CDT cells kill infected or malignant cell

Answer 8

1. secretion of cytokines or INF-g and TNFa which have anti tumor and anti viral microbial effects
2. release of cytotoxic granules containing perforin, granzyme and leading to apoptosis of target cells
3. fas-fas L interaction
   - fas is on the surface of CD8 t cells binds fas on target cells and activates caspade cascade and apoptosis

Question 9

egg protien

Answer 9

Gal d 1-5

Question 10

fish protein

Answer 10

Gad d5

Question 11

shrimp protein

Answer 11

Lit v1, Pen a 1

Question 12

apple protein

Answer 12

mal d1, 2

Question 13

CVID definition

Answer 13

1. marked decrease of IgG with low IgM and IgA
2. Decrease response to immunizations
3. absence of other PID
4. age > 4 years

Question 14

dosing of acarizax

Answer 14

12 SQ HDM

Question 15

dosing of grastek

Answer 15

2800 BAU

Question 16

Oralair

Answer 16

300 IR

Question 17

ragwitek

Answer 17

12 Amb AI U

Question 18

MWS triad

Answer 18

1. progressive sensorineural hearing loss
2. secondary AA with nephropathy
3. intermittent episodes of fever, headache, urticaria, and joint pain

Question 19

labs in acquired angioedema

Answer 19

1. low C4
2. low C1q
3. low of normal C1inh levels

Question 20

3 reagents used in Penicillin testing

Answer 20

1. Pre pen (penicilloyl-polylysine)
2. Amoxicillin
3. Pen G
4. Penicilloate
5. Penilloate

Question 21

ciclesonide

Answer 21

omnaris

Question 22

fluticase furoate

Answer 22

arnuity

Question 23

fluticasone proprionate

Answer 23

flovent

Question 24

aerius

Answer 24

desloratidine

Question 25

elidel

Answer 25

pimecrolimus

Question 26

cinquair

Answer 26

resilizumab

Question 27

dymista

Answer 27

azelastine/ fluticasone proprionate

Question 28

CI to penicillin skin testing

Answer 28

i. Overlying skin condition that might interfere with interpretation or overlying skin infection ii. Inability to discontinue medications that might interfere with testing iii. History of SCAR to penicillin

Question 29

Approximately what percent of individuals with latex allergy have associated hypersensitivity to a related food?

Answer 29

30-50%

Question 30

Describe how you would evaluate a patient with suspected allergic reaction to a local anesthetic.

Answer 30

- Skin test with undiluted LA (ideally mention using preparation without epinephrine) - Intradermal with diluted LA (1:100 ideally mentioned, 1:10 could be accepted) - If positive, evaluate other LAs for safe alternative - If negative, mention challenge Mention protocol (1-3 steps, with or without single-blind saline step, as long as reasonable)

Question 31

significance of IFN-g/ IL4 ratio

Answer 31

it goes up in AIT

Question 32

ACEi should be considered for discontinuation in which situation?

Answer 32

VIT

Question 33

benefits of SLIT

Answer 33

1. home administration 2. increased stability and ensured standardization of dosing 3. improved reliability in dosing and compliance 4. FDA approved products

Question 34

fatality rate of SCIT

Answer 34

1 in 2 million injections

Question 35

Rfs for asthma mortality

Answer 35

1. past history of sudden, severe exacerbations 2. prior intubation and ICU management 3. >2 hospitalizations for asthma in past two years 4. >3 ED visits for asthma in past year 5. poor perceivers of dyspnea 6. low SES

Question 36

filaggrin is part of which skin layer?

Answer 36

stratum corneum

Question 37

which cytokine is important in pruritus and why?

Answer 37

IL-31 expresses IL4 and IL13 | s. aureus super antigen rapidly induces IL31

Question 38

chemokines increased in AD

Answer 38

1. RANTES 2. MCP-4 3. eotaxin

Question 39

Hanifin and Rajka Criteria

Answer 39

Major 1. pruritus 2. facial or extensor involvement in kids 3. flexural lichenificantion in older children and adults 4. chronic or relapsing dermatitis 5. personal or family history of atopic disease

Question 40

occular problems w AD

Answer 40

1. atopic keratoconjunctivitis eyelid dermatitis due to increased # IgE bearing langerhans cells 2. keratoconus - corneal deformity from eye rubbing 3. anterior subscapular cataracts

Question 41

Crisaborole

Answer 41

PDE4 inhibitor | Eucrisita