Pre-hepatic jaundice cause
RBC breakdown –> produces excess bilirubin
Hepatocellular jaundice cause
Hepatocyte damage
- inability to metabolise unconjugated bilirubin from bloodstream
Obstructive Jaundice causes
Cholestasis
- Gallstones
- Pancreatic Adenocarcinoma
Obstructive jaundice features
High ALP & GGT
Hepatocellular jaundice features
High ALT & AST
Pre-hepatic jaundice features
Pt often anaemic due to lack of RBC
- LFTs usually normal
Diagnosis may be Gilbert’s syndrome if no anaemia is present
Complications of portal HTN