Least specialized, most common
Fibroblasts + macrophages
immune cells
Mast cells + plasma cells
Most specialized, tissue specific
Chondrocytes + Osteocytes + Adipocytes + myoepithelial
What are the 3 Cell-ECM interactions
Focal adhesions, integrins, hemidesmosomes
intracellular actin filament + transmembrane integrin anchor cells to basal lamina
Focal Adhesions
Attach cells to ECM
Integrins
intracellular intermediate filament + trans-membrane integrin anchor cells to basal lamina
Hemidesmosomes
The layer between the cell and the amorphous connective tissue, also known as the basement membrane
Basal Lamina
Laminin
adhesive protein stickiness
Collagen
Fibrous protein strength
Integrin
connect cell to basal lamina
Major adhesive protein in the ECM, long and sticky, can bind: Itself, collagen, other ECM components, cells
fibronectin
protein synthesized in the cell, GAG sugars added in ER/Golgi, released by exocytosis into the extracellular space attached to protein module
Proteoglycans
Hydrophobic, long, unbranched chain of sugars
GAG
Major component of cartilage, made on the plasma membrane, produced in large quantities for wound repair
Extreme GAG = Hyaluronic acid
fibrous protein secreted by connective tissue cells, triplet of amino acids: Gly-Pro-X. Form a fibril then a fiber
Collagen
Makes connective tissue flexible, lots of proline and glycine but little hydroxylation or glycosylation, crosslinking essential
Elastin
