IBD - EPI
18 - 24, then 70+
Big cities
America
Genetic (monozygotic twins 60%, children 10%, siblings 10%)
Crohn’s Disease
Patchy inflammation Mouth to anus involvement Transmural inflammation Fistulas and strictures common Risk of cancer Extraintestinal mainfestations Higher risk for smokers Can have granulomas
Ulcerative Colitis
Continuous inflammation Generally affects the colon Mucosal inflammation Fistulas and strictures seldom Risk of colorectal cancer Extraintestinal manifestations Lower risk for smokers Granulomas uncommon
Ulcerative Colitis - Practical
Always bleeds
Only involves the colon
Protected by smoking
Extraintestinal Mainfestations of IBD
Ocular disorders Aphthous stomatitis Ankylosing spondylitis Nephrolithiasis Sacroileitis Thromboembolic complications Skin disorders Peripheral arthritis Primary sclerosing cholangitis Hepatobiliary disorders
Venn Diagram of IBD
Luminal Antigens
Genetic Susceptibility
Environmental Triggers