G protein involved in cAMP pathway
Gs: inc cAMP
Gi: dec cAMP
Adenylate cyclase
Protein kinase in cAMP pathway
protein kinase A
Examples in cAMP pathway
glucagon
epi (a2,b1)
G proteins in IP3/DAG
Gq
phospholipase C
Protein kinase in IP3/DAG
Protein kinase C
Example in IP3/DAG pathway
epi (a1)
Protein kinase in cGMP
Protein kinase G
Example on cGMP pathway
ANP
NO
Protein kinase in tyrosine kinase pathway
tyrosine kinase/ JAK-STAT
Example in tyrosine kinase pathway
Insulin
Growth factors
Example in intracellular pathway
glucocorticoids
thyroid hormones
The 5 2nd messenger systems
cAMP IP3/ DAG cGMP Tyrosine kinase Intracellular