30: RA

Question 1

specific HLA linked to RA

Answer 1

DRB-4

Question 2

RA in pregnancy

Answer 2

improves while pregnant, flares 4-6wks post-partum

Question 3

what way does the wrist tend to deviate in RA

Answer 3

radial deviation

Question 4

pyoderma gangrenosum

Answer 4

tender red/purple papules -> necrotic, non-healing ulcers in RA

Question 5

lung things that can happen with RA

Answer 5

pleuritis (MC), nodules, ILD, Caplan syndrome (nodules after coal/silica exposure), pulmonary fibrosis

Question 6

what is the eye dryness test for sjogren’s called?

Answer 6

Schirmer’s test

Question 7

Felty’s syndrome

Answer 7

RA + fever, splenomegaly, pancytopenia

Question 8

C spine in RA

Answer 8

erosion of odontoid process, weak transverse ligament

Question 9

when else can RF be positive besides RA?

Answer 9

1. 1-4% of healthy elderly pts
2. viral hepatitis
3. CTD, SLE, polymyositis, Sjogren’s, CREST
4. lymphoma, myeloma
5. Tb, mono, syphylis, sarcoid

Question 10

two ways steroids are used in RA

Answer 10

1. bridge therapy before DMARDs

2. flare ups

Question 11

toxicities of all biologics

Answer 11

1. increased infection
2. Tb reactivation
3. neoplasias
4. MS
5. autoimmune dz

Question 12

dactylitis

Answer 12

swelling of fingers/toes

Question 13

enthesitis

Answer 13

ligament or tendon attachment to bone due to inflammatory changes

Question 14

spondylitis

Answer 14

inflammation of a vertebrae

Question 15

spondylolisthesis

Answer 15

anterior displacement of a vertebral body relative to the adjacent

Question 16

schober test

Answer 16

measures flexion of lumbar spine, is positive in ankylosing spondylitis

Question 17

major treatment for ankylosing spondylitis

Answer 17

movement - slows disease progression to move/exercise

Question 18

circunate balanitis and keratoderma blennorrhagicum are associated with which condition?

Answer 18

reactive arthritis

Question 19

treatment for seronegative arthropathies

Answer 19

exercise, NSAIDs, glucocorticoids, methotrexate, DMARDs