34

Question 1

Selective toxicity - Paul enrich

Answer 1

• early treatments for infectious diseases (such as syphillis) involved the use of highly toxic ‘medicines’ more harmful then the actual disease
• pull ehrlich, notes that some dyes (such as methylene blue) stained microbes better then host cells
• he came up with the idea of a chemical ‘ magic bullet’ to kill microbes but not the host cells
• 1909 the first elective antibiotic Salvarsan or compound 606

Question 2

Selective toxicity is..

Answer 2

Something that can kill microbes but not the host

Question 3

Penicillin - Alexandra Fleming

Answer 3

In 1982 Alexander Fleming observed that colonies of the bacterium staphyloccoccus bacteria could be destroyed by the mold penicilium notatum

Question 4

How does penicillin work (def in exam)

Answer 4

• inferring with the normal formation of the bacterial cell wall by inhibiting the formation of peptidoglycan cross-li is

Question 5

Penicillin shit

Answer 5

Different antibiotics are used for different bacteria
Antibiotic for every different part of the bacteria
Mainly

Question 6

How bacteria become resistant to the penicillin

Answer 6

• mutation that allowed resistance to penicillin

Question 7

Beta lactamase

Answer 7

• enzyme procured by bacteria and used to destroy penicillin ring
• mutation ususally found on a plasmid encode for beta lactamase
• beta lactamase is responsible for breaking the benzene ring on penicillin

Question 8

How many reisitant factors on one plasmid

Answer 8

Many

Question 9

Ajt9robic resistance - vertical and horizontal

Answer 9

• hroicaontla transfer can also happen across species

Question 10

How to reduce antibiotic resistance

Answer 10