physiologic dead space is = to
VD = anatomic dead space + functional dead space
physiologic dead space = volume of conducting airways + alveoli that not participate in gas xchange
minute ventilation
total rate of air movement into/out of lungs
= tidal volume x respiration rate
alveolar minute ventilation
rate that new air reaches the gas exchange areas of lungs
= respiration rate x (tital vol - dead space)
effects on alveolar minute ventilation
inc respiration rate and dec tidal vol = greater proportion of alveolar ventilation contributing to dead space
inc tidal vol greater effect that respiration rate
spirometry
measure lung volumes and air flow
-shown on a graph, slope = airflow
need other tests for helium dilution, whole body plethysmograph, esophageal balloon
imaging
forced vital capacity
total vol that can be forcibly expired after maximal inspiration
lung volume differences in obstructive vs restrictive
restricted = dec all lung vols
obstructive = inc in TLC, inc residual, inc FRC
spirometry analysis of obstructive
graph can show flat inspiratory cuve, flat expiratory, or both
-if upper airway obstruct then variable or fixed
common causes are tumors and fibrotic structures
spirometry analysis of restrictive
lung vols are lower in general
-dec vital capacity, IC, lower RV/ERV/FRC
looks like an orange slice
evaluating FEV1 and FVC
normal ratio = 0.8
obstruct = FEV1 < FVC so dec ratio <0.7
restrict = FEV1 > FVC so ratio inc