4.1 Quantitative Defect in platelets

Question 1

Most common cause of cinically importane bleeding

Answer 1

Thrombocytopenia

Question 2

Manifest as small-vessel bleeding:

Small pinpoint hemorrhagic spots (<3mm)

Answer 2

Petechiae

Question 3

Purplish skin discoloration observed in mucocutaneous bleeding (3mm to cm)

Answer 3

Purpura

Question 4

Leakage of blood into large aras of the skin; Irregular bluish patch (1cm)

Answer 4

Ecchymosis

Question 5

Risk for clinical bleeding increases progressively as the platelet count decrease from __________

Answer 5

50,000 /uL

or

<50x10^9/L

Question 6

Decrease Platelet production may associated with:

• Fanconi anemia
• May-Hegglin anomaly
• Wsikott-Aldrich syndrome
  -Bernard-soulier syndrome

T or F

Answer 6

T

Question 7

Decreased plt count may associated with

Thrombocytopenia with absent radius (TAR) syndrome

T or F

Answer 7

T

Question 8

Increase platelet destruction may include:

• Idiopathic thrombocytopenic purpura
• Drug induced
• Neonatal alloimmune/autoimmune thrombocytopenia
• Post transfusion purpua

T or F

Answer 8

T

Question 9

Non immune cause of increase platelet destuction are:

• Gestational thrombocytopenia, HDN
• TTP
• HUS
• DIC

T or F

Answer 9

T

Question 10

ADAMTS13 cleaves vWP

T or F

Answer 10

T

Question 11

Abnormal platelet distribution (Sequestration) is a condition associated with?

Answer 11

Splenomegaly

Question 12

Abnormal platelet distribution may cause by lowering the body temp to less than 25 C

T or F

Answer 12

T

Question 13

Abnormal platelet distribution may cause by massive whole blood transfusion

T or F

Answer 13

T