4.3 - Eicosanoids

Question 1

Eicosanoids

Answer 1

• Biosynthesis

* Effects

Question 2

Biosynthesis

Answer 2

Sources

Question 3

Sources

Answer 3

• Phospholipids (major)
• Phosphatidyl inositol (alternative)
⬇️⬇️⬇️
Arachidonic Acid

Question 4

Phospholipids ➡️ Arachidonic Acid

Answer 4

Phospholipase A2

Question 5

Phosphatidyl inositol ➡️ Arachidonic Acid

Answer 5

Phospholipase C

Question 6

Arachidonic Acid
⬇️
– Prostaglandins
– Thronboxanes
– Prostacyclin (PGI2)

Answer 6

Cycolooxygenase (COX)

Question 7

Arachidonic Acid
⬇️
Leukotrienes

Answer 7

5-Lipoxygenase (LOX)

Question 8

– 5, 8, 11, 14-eicosatetraenoic acid

– 20C; 4 double bond

Answer 8

Arachidonic Acid

Question 9

Cyclooxygenase

Answer 9

• Prostaglandins
• Thromboxanes
• Prostacyclin (PGI2)

Question 11

– Cytoprotection
– Vasodilation
– Pain & Inflammation

Answer 11

Prostaglandins

Question 12

– Platelet aggregation

– Vasoconstriction

Answer 12

Thromboxanes

Question 13

5-Lipooxygenase

Answer 13

Leukotrienes

Question 14

Leukotrienes

Answer 14

• LTB4

* LTC4/ LTD4

Question 15

– Chemotactic factor

– Induces the movement of immune cells

Answer 15

LTB4

Question 16

– SRSAs

– Slow-reacting substance of Anaphylaxis

Answer 16

LTC4/ LTD4

Question 17

Effects

Answer 17

• Blood vessels
• Bronchi
• GIT
• Platelets
• Uterus
• Reduction of intraocular pressure

Question 18

Blood vessels

Answer 18

• Vasodilation

* Vasoconstriction

Question 19

Vasodilation

Answer 19

• PGI2 (Prostacyclin)

* PGE series

Question 20

Vasoconstriction

Answer 20

• TXA2

* PGF2a

Question 21

Bronchi

Answer 21

• Bronchodilation

* Bronchoconstriction

Question 22

Bronchodilation

Answer 22

• PGI2

* PGE series

Question 23

Bronchoconstriction

Answer 23

• LTC4

* LTD4

Question 24

GIT

Answer 24

Cytoprotection

– PGE1

Question 25

Platelets

Answer 25

• Platelet aggregation

* Inhibition of platelet aggregation

Question 26

Platelet aggregation

Answer 26

TXA2

Question 27

✖️ Platelet Aggregation

Answer 27

* PGI2 | * PGE1

Question 28

Uterus — PGE series — PGF2a

Answer 28

* Contraction | * Dysmenorrhea

Question 29

Reduction of Intraocular Pressure

Answer 29

– PGF2a | – PGE series

Question 30

Drugs

Answer 30

* Epoprosterenol * Misoprostol * Alprostadil * Dinoprostone * Latanoprost * Carboprost tromethamine

Question 31

PGI2

Answer 31

Epoprosterenol

Question 32

PGE1

Answer 32

* Misoprostol | * Alprostadil

Question 33

PGE2

Answer 33

Dinoprostone

Question 34

PGF2a

Answer 34

* Latanoprost | * Carboprost tromethamine

Question 35

– Mgt of primary pulmonary HTN (vasodilator) ** Silfenafil — PDE5 inhibitor (Revatio®)

Answer 35

Epoprosterenol

Question 36

``` – Use: - Cytoprotectant - Mgt OF PUD — NSAID induced – S/E: - abortion ```

Answer 36

Misoprostol

Question 37

– Mgt of erectile dysfunction | – Maintain the patency of the ductus arteriosus

Answer 37

Alprostadil

Question 38

– cervical ripening | – abortifacient (vaginal suppository)

Answer 38

Dinoprostone

Question 39

– Mgt of Galucoma | - Xalatan®

Answer 39

Latanoprost

Question 40

– Abortifacient

Answer 40

Carboprost tromethamine

Question 41

– Vasodilation | – Inhibits platelet aggregation

Answer 41

Prostacyclin (PGI2)