What are the 3 variants of primary progressive aphasia?
T/F: Each variant has its own neuroanatomical correlates.
True
T/F: Only one variant can exist at a time.
False
These variants can be mixed together, but presentation will vary depending on the patient
Describe the onset & progression of PPA.
Insidious onset
Gradual progression
To be diagnosed with PPA, the patient MUST HAVE… (3)
PPA is a subtype of _____________ dementia where the initial & main symptoms are languaged-focused.
Frontotemporal dementia
Which neuropathophysiology is associated with nonfluent agrammatic variant PPA? (2)
Unilateral
Inferior frontal part of the dominant language hemisphere
For nonfluent agrammatic variant PPA’s criteria,
AT LEAST ONE must be present:
1. ?
2. ?
Agrammatism
Apraxia of speech
For nonfluent agrammatic variant PPA’s criteria,
AT LEAST 2 of the following 3 features:
1. ?
2. ?
3. ?
In nonfluent agrammatic variant PPA, the more severe, then the ________ random the errors
more
The neuropathophysiology of nonfluent agrammatic variant PPA is similar to which type of aphasia?
Broca’s aphasia
Neurogenic stuttering is a characteristic of which PPA variant?
nonfluent agrammatic variant PPA
Describe the neuropathophysiology associated with fluent (semantic) variant PPA? (2)
Bilateral
Anterior temporal lobes
Compare typical semantic variant PPA vs semantic dementia.
Typical semantic variant PPA: progressive language disorder characterized by the loss of word meanings
Semantic dementia: a neurodegenerative disorder characterized by loss of broad semantic knowledge (language, objects, faces)
If bilateral, anterior temporal lobes are damage…
1. + left hemisphere is more prominent, then…
2. + right hemisphere is more prominent, then…
For fluent (semantic) variant PPA’s criteria…
BOTH must be present:
1. ?
2. ?
For fluent (semantic) variant PPA’s criteria…
AT LEAST 3 of the following 4 features:
1. ?
2. ?
3. ?
4. ?
If asked to draw 2 different animals, how would you expect a client with fluent (semantic) variant PPA to perform? (1)
Over time, the drawing would have similar features, demonstrating loss of semantic features
Out of the 3 variants, people with which PPA variant can compensate for the longest & why?
fluent (semantic) variant PPA
Why? Generally preserved syntax, phonology, & prosody
Describe the neuropathophysiology associated with logopenic variant. (2)
Unilateral
Posterior temporal regions
What other disease has a similar neuropathophysiology to logopenic variant PPA?
Alzheimer’s disease also starts at the posterior temporal region, BUT BILATERALLY
For logopenic variant PPA’s criteria…
BOTH must be present:
1. ?
2. ?
For logopenic variant PPA’s criteria…
AT LEAST 3 of the following 4 features:
1. ?
2. ?
3. ?
4. ?
*3+4 DDx from nonfluent variant PPA
______________ test can be used to diagnose PPA.
Mini Linguistic State Exam