5 PPA Flashcards

(57 cards)

1
Q

What are the 3 variants of primary progressive aphasia?

A
  1. Nonfluent agrammatic variant
  2. Fluent (semantic) variant
  3. Logopenic variant
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2
Q

T/F: Each variant has its own neuroanatomical correlates.

A

True

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3
Q

T/F: Only one variant can exist at a time.

A

False

These variants can be mixed together, but presentation will vary depending on the patient

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4
Q

Describe the onset & progression of PPA.

A

Insidious onset

Gradual progression

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5
Q

To be diagnosed with PPA, the patient MUST HAVE… (3)

A
  1. Language impairment is the most prominent feature
  2. Language difficulty is causing impaired ADLs
  3. Aphasia is the most prominent feature at onset & early stages
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6
Q

PPA is a subtype of _____________ dementia where the initial & main symptoms are languaged-focused.

A

Frontotemporal dementia

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7
Q

Which neuropathophysiology is associated with nonfluent agrammatic variant PPA? (2)

A

Unilateral

Inferior frontal part of the dominant language hemisphere

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8
Q

For nonfluent agrammatic variant PPA’s criteria,

AT LEAST ONE must be present:
1. ?
2. ?

A

Agrammatism
Apraxia of speech

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9
Q

For nonfluent agrammatic variant PPA’s criteria,

AT LEAST 2 of the following 3 features:
1. ?
2. ?
3. ?

A
  1. Impaired complex syntax
  2. Spared comprehension of single words*
  3. Spared object knowledge*
  • 2 & 3 go together since they test semantic knowledge
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10
Q

In nonfluent agrammatic variant PPA, the more severe, then the ________ random the errors

A

more

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11
Q

The neuropathophysiology of nonfluent agrammatic variant PPA is similar to which type of aphasia?

A

Broca’s aphasia

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12
Q

Neurogenic stuttering is a characteristic of which PPA variant?

A

nonfluent agrammatic variant PPA

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13
Q

Describe the neuropathophysiology associated with fluent (semantic) variant PPA? (2)

A

Bilateral
Anterior temporal lobes

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14
Q

Compare typical semantic variant PPA vs semantic dementia.

A

Typical semantic variant PPA: progressive language disorder characterized by the loss of word meanings

Semantic dementia: a neurodegenerative disorder characterized by loss of broad semantic knowledge (language, objects, faces)

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15
Q

If bilateral, anterior temporal lobes are damage…
1. + left hemisphere is more prominent, then…
2. + right hemisphere is more prominent, then…

A
    • left hemisphere is more prominent, then typical semantic variant PPA
    • right hemisphere is more prominent, then semantic dementia
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16
Q

For fluent (semantic) variant PPA’s criteria…

BOTH must be present:
1. ?
2. ?

A
  1. Impaired confrontation naming
  2. Impaired comprehension of single words
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17
Q

For fluent (semantic) variant PPA’s criteria…

AT LEAST 3 of the following 4 features:
1. ?
2. ?
3. ?
4. ?

A
  1. Impaired object knowledge
  2. Surface dyslexia/dysgraphia
  3. Spared repetition
  4. Spared syntax & motor speech
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18
Q

If asked to draw 2 different animals, how would you expect a client with fluent (semantic) variant PPA to perform? (1)

A

Over time, the drawing would have similar features, demonstrating loss of semantic features

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19
Q

Out of the 3 variants, people with which PPA variant can compensate for the longest & why?

A

fluent (semantic) variant PPA

Why? Generally preserved syntax, phonology, & prosody

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20
Q

Describe the neuropathophysiology associated with logopenic variant. (2)

A

Unilateral
Posterior temporal regions

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21
Q

What other disease has a similar neuropathophysiology to logopenic variant PPA?

A

Alzheimer’s disease also starts at the posterior temporal region, BUT BILATERALLY

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22
Q

For logopenic variant PPA’s criteria…

BOTH must be present:
1. ?
2. ?

A
  1. Impaired single word retrieval (naming & conversation)
  2. Impaired repetition of sentences & phrases
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23
Q

For logopenic variant PPA’s criteria…

AT LEAST 3 of the following 4 features:
1. ?
2. ?
3. ?
4. ?

A
  1. Phonologic errors on naming & in conversation
  2. Spared single-word comprehension & object knowledge
  3. Spared motor speech*
  4. Absence of agrammatism*

*3+4 DDx from nonfluent variant PPA

24
Q

______________ test can be used to diagnose PPA.

A

Mini Linguistic State Exam

25
Mini Linguistic State Exam looks at which 5 factors?
1. Motor speech 2. Working memory 3. Semantics 4. Syntax 5. Phonology
26
According to the MLSE, which are the prominent feature in each variant? 1. Nonfluent PPA 2. Fluent (semantic) PPA 3. Logopenic PPA
1. Nonfluent PPA: phonology & syntax 2. Fluent (semantic) PPA: semantics, then working memory 3. Logopenic PPA: working memory & syntax
27
PPA progreses as language function slowly declines turning PPA into ______.
PPA+
28
Describe nonfluent (agrammatic) variant PPA vs PPA+?
Nonfluent PPA: grammar or motor speech deficit Nonfluent PPA+: problems with EFs, swallowing, motor function, & other diseases
29
Describe fluent (semantic) variant PPA vs PPA+?
Fluent PPA: single word comprehension deficit Fluent PPA+: change in behaviour & personality deficits recognizing faces & objects
30
Describe logopenic variant PPA vs PPA+?
Logopenic PPA: Word finding, oral repetition Logopenic PPA+: problems with working memory and/or memory in general, possible DAT
31
What types of intervention approaches did we discuss in class for PPA? (5)
Language Speech Group Intervention Adjuvant therapies Computerized approaches
32
What are some examples of a language intervention approach in PPA? (2)
- Lexical retrieval (e.g., phonemic/semantic feature analysis, spaced retrieval, errorless approach, etc.) - Syntax (e.g., mapping theory) (nfPPA)
33
What is an example of a speech intervention approach in PPA?
Script training (nfPPA)
34
What is an example of group intervention in PPA? - Baycrest? - Aphasia Institute?
Baycrest hybrid model = individual therapy, group discussion, caregiver support, counselling, education Aphasia Institute = supported conversation groups
35
What is an example of adjuvant therapies in PPA? (1)
Transcranial direct current stimulation + lexical retrieval
36
What are some examples of computerized approaches in PPA? (2)
Internet-based (wordfinding.ca) Apps (TACTUS)
37
T/F: Relearning is not possible in PPA therapy.
False
38
What treatment methodology were found to be efficacious in Jokel et al.'s study? (4)
Computer-based ix Cued naming Orthography Combined orthographic & phonological cues
39
What factors are shown to increase success in therapy? (3)
- Personal familiarity with items linked to the patients' autobiographical experiences - Oraganizing words in semantic categories - Partially spared semantic knowledge facilitates re-learning (-N +C)
40
In the PPA studies, it was found that better maintenance of ________ items than ________ items occurred.
Trained > untrained
41
Compare errorful learning vs errorless learning.
Errorful learning = mistakes are allowed Errorless learning = mistakes are not allowed
42
What is a passive/effortless approach in ERRORFUL LEARNING? (2)
- Patient is given incorrect options & must eliminate - Patient guesses the target
43
What is an active/effortful approach in ERRORFUL LEARNING? (2)
- Patient is given broad questions - Patient must retrieve the target by guessing
44
What is a passive/effortless approach in ERRORLESS LEARNING? (2)
- Patient is given all the information needed to get the target - Fully supported by clinician
45
What is an active/effortful approach in ERRORLESS LEARNING? (2)
- Clinician gives guiding questions - Patient responds only if 100% sure
46
Compare the results of errorful vs errorless learning on PRODUCTION. (4)
1. Errorful passive (least correct responses) 2. Errorful active 3. Errorless passive 4. Errorless active (most correct responses)
47
Compare the results of errorful vs errorless learning on COMPREHENSION. (1)
No method effect on word recognition (all the same)
48
Explain maladaptive/compensatory activation (2).
- During a task, activation occurs in other brain regions. - The specific region is too damaged beyond repair, requiring other networks to provide support.
49
T/F: Maladaptive/compensatory activation always occurs when there is neural damage.
False Only occurs if the brain is too damaged. If not overwhelmingly damaged, then there is residual functioning.
50
T/F: Since PPA is a progressive disease, no more gains can be made in therapy after 6mo.
False There are still gains in therapy up to 6mo despite it being a progressive condition Take advantage of the window of onset of PPA & get lots of therapy to help them for as long as you can
51
What are the benefits of language tx in PPA (all variants)? (6)
1. Post-tx improvements 2. Active participation 3. Relearning of words for daily functioning 4. Generalization (items, contexts) 5. Maintenance with practice! 6. Neuroplasticity
52
PPA group therapy is a group intervention for _______ & their ________.
clients spouses
53
T/F: PPA group therapy involves goals targeted for both the client and their spouse
True
54
List the 4 goals of PPA group therapy (1, 2, 3, 4abc)
1. Provide education abt PPA 2. Offer communication opportunities for people with PPA 3. Teach communication strategies 4. Provide a safe forum for: exchange of ideas, practicing strategies, sharing experiences of PPA
55
Describe an example of the structure for PPA group therapy. (4)
10 weeks 2h sessions 1h - Client works on their communication. Spouses network with other spouses, SW, SLP. 2h - Spouses join for education or communication strategies.
56
What outcome measures can be used for PPA group therapy? (2)
A quality of communication life scale - for client Spousal questionnaires- for spouse
57