5HT system

Question 1

Cushing’s disease

Answer 1

constant glucocorticoid release
obesity
depression
psychosis
buffalo hump

Question 2

showerhead principle

Answer 2

one source of 5HT = raphe nucleus
gets everywhere
acts as neuromodulator

Question 3

5HT origin

Answer 3

synthesised from tryptophan
although removing it from diet only has effect in 50%
in raphe nucleus

Question 4

5HT-4 receptor

Answer 4

only expressed in gut
can be targeted
so no psychotropic effect

Question 5

third dopamine system

Answer 5

in hypothalamus
blocks lactate system