7.3.5 Acylation

Question 1

How are acyl chlorides made?

Answer 1

• Substituting a Cl atom for the OH group
• In a carboxylic acid
• oyl Chloride

Question 2

How are acid anhydrides made?

Answer 2

• Substitution of OH group in a carboxylic acid
• With an alkanoate
• oic anhydride

Question 3

What reactions do acyl chlorides undergo?

Answer 3

• Nucleophilic addition-elimination reactions
• Eg. Hydrolysis, alcohols -> Esters, forming amides

Question 4

How does hydrolysis of Acyl chlorides work?

Answer 4

• Forms carboxylic acid and HCL
• Nucleophilic addition-elimination reaction
• H2O added across C=O bond
• HCl eliminated

Question 5

How does formation of esters work from acyl chlorides?

Answer 5

• React Acyl chlorides with Alcohols
• Forming esters
• Nucleophilic addition-elimination reaction
• OH adds across C=O bond
• HCL eliminated