8.2

Question 1

What bacteria is bacitracin indicated for?

Answer 1

Gram + only

Question 2

What enzyme does Fosfomycin inhibit?

Answer 2

Enol-pyruvate transferase

Question 3

What are the drugs in the class tetracyclines?

Answer 3

1) Doxycycline
2) Minocycline
3) Tetracycline

Question 4

How do tetracyclines get into the cell?

Answer 4

Passive diffusion and energy dependent transport unique to bacterial inner cytoplasmic membrane

Question 5

What is the MOA of tetracyclines?

Answer 5

Binds reversibly to 30 s subunit of ribosome

Question 6

What are the 3 main mechanisms by which Tetracyclines gain resistance?

Answer 6

• Impaired influx or increased efflux by active protein pump
• Production of proteins that interfere with binding to ribosome
• Enzymatic inactivation

Question 7

What is the most common use of tetracyclines?

Answer 7

Severe acne and rosacea

Question 8

If someone has a penecillin allergy, what can be given to a patient with syphillis?

Answer 8

Tetracycline

Question 9

Tetracyclines can be used in combination for? (3)

Answer 9

• H.pylori eradication
• Malaria prophylaxis and treatment
• Treatment of plague, tularemia, brucellosis

Question 10

Where does tetracycline concentrate? (4)

Answer 10

Kidney
Liver
Spleen
Skin

Question 11

Can tetracyclines be given in pregnancy?

Answer 11

• NO. They are teratogenic. All cross placenta and are excreted into breast milk.
• Category D.