Abnormal coagulation

Question 1

Heparin

Answer 1

Prevents activation factors 2, 9, 10 and 11

Question 2

Warfarin

Answer 2

Affects synthesis of factors 2, 7, 9 and 10

Question 3

DIC

Answer 3

Factors 1, 2, 5, 8 and 11

Question 4

Liver disease

Answer 4

Factors 1, 2, 5, 7, 9, 10 and 11

Question 5

Haemophilia

Answer 5

Increased APTT, normal PT and normal bleeding time

Question 6

von Willebrand’s disease

Answer 6

Increased APTT, normal PT and increased bleeding time

Question 7

Vitamin K deficiency

Answer 7

Increased APTT, increased PT and normal bleeding time

Question 8

Tranexamic acid

Answer 8

Inhibits plasmin -> prevents fibrin degradation

Question 9

Tranexamic acid

Answer 9

Inhibits plasmin -> prevents fibrin degradation

Question 10

Which factors are sensitive to temperature?

Answer 10

Factors V and VIII