Pinch off syndrome
Catheter compressed between first rib and clavicle, causing intermittent compression and pinching leading to intermittent occlusion of the infusion and aspiration
Superior vena cava syndrome
SVCS is caused when the flow of blood in the SVC vein slows.
Superior vena cava syndrome symptoms
Swelling also seen in catheter migration - but is less extensive and just includes neck and/or chest
Catheter migration & symptoms
This occurs when the catheter has moved from where it was first placed
Signs of a migrated catheter include:
Swelling also seen in superior vena cava syndrome - but is more extensive
Thrombotic catheter occlusions include:
Formation of thrombus within, surrounding, or at tip of catheter
Fibrin tail or flap
Intraluminal thrombus
Mural thrombus
Fibrin sheath
Management of thrombotic occlusions
Proper flushing AKA Pulsatile flushing technique
Declotting solutions
Inability to aspirate blood but still having ability to infuse through CVC suggests what type of occlusion?
A. Pinch off syndrome
B. Intraluminal thrombus
C. Calcium phosphate precipitate occlusion
D. Fibrin sheath/tail
Fibrin sheath/tail
How do intraluminal thrombus and calcium precipitate typically present?
Inability to infuse
Inability to aspirate
Nonthrombotic catheter occlusions include:
Precipitates
- Drug crystallization
- Drug-drug incompatibilities
- Drug-solution incompatibilities
Mechanical and malposition obstructions:
- Clamp on catheter
- Kinked catheter
- Tight retaining suture
- Pinch off syndrome
- Migration
Lipid residue
- Can accumulate in central venous catheters
- Often follows the administration of lipid-containing, TNA or drugs with oleaginous vehicles
Drug precipitates in the catheter may occur in conjunction with thrombus formation and should always be considered during assessment of an occlusion, since this may have implications for how the occlusion should be managed
How to manage precipitate occlusions
0.1 N hydrochloric acid
* Acidic precipitates (pH <6) like vancomycin, calcium-phosphate precipitates
70% ethyl alcohol or sodium hydroxide (0.1 mmol/mL)
* Lipid residue/precipitates
Sodium bicarbonate (1 mEq/mL)
* Alkaline drug precipitate (pH >7) like phenytoin or oxacillin
Lipids are soluble in alcohol
Temporary non-tunneled central catheter
Quick access device placed in emergencies or in ICUs
* Triple lumen subclavian, percutaneous, acute-care catheter, CVP
* Short term: 7-10 days
* Not for home use
Peripherally insterted central catheter (PICC)
Inserted in peripheral vein (upper arm), with tip terminating in SVC/ right arterial junction
* Single, double, triple lumen
* Long term and widely used
* Not preferred for PN at home - need nurse for sterile dressing changes
Internal Jugular (IJ)
Utilized in renal disease
* Allows preservation of peripheral and subclavian veins for AVF or grafts
Tunneled cuffed central catheters
Surgically placed, for long term use
Implanted port
Surgically placed in subcutaneous pocket anterior chest or arm
* Long term, minimal alteration in body image
* Lower infection and thrombosis rates
* Silicone catheter attached to plastic or titanium disk
* Access using ONLY non coring needle
* Can be accessed 1000-2000 x
Antibiotic lock therapy
Results in interruption of TPN in setting of line infection
* May result in hyper-resistance
* Targeted therapy
Ethyl alcohol lock therapy
25-70% solutions which kill bacteria and fungi
* Decreases adherence of bacteria
* Reduces incidence of CLABSI
Taurolidine
Derivative of AA Taurine
* Not in US
* Broad spectrum antiseptic, preventing growth of bacteria and fungi
* Is not an antibiotic
Silicone catheter
Pliable, less traumatic to veins
* Able to instill ethanol lock solution
Polyurethane catheter