ACE-I

Question 1

Mode of Action

Answer 1

Angiotensinogen –> Ang I –> Ang II
ACE
Bradykinin –> Inactive peptide

Question 2

Roles of Ang II and Bradykinin

Answer 2

Ang II: Potent vasoconstrictor, inducer of Na+ and H2O retention

Bradykinin: Potent vasodilator

Question 3

ACE enzyme characteristics

Answer 3

Zn protease
Mechanism similar to carboxypeptidase
Hydrolyses C-terminal dipeptide

3D structure orginally unknown