ACE test

Question 1

What is ACE 3?

Answer 1

Addenbrooke’s Cognitive Examination‐III (ACE‐III) is a brief (20-30 minutes) cognitive screening measure widely used for diagnosing and monitoring dementia and other neurological conditions, such as motor neuron disease

Question 2

What does ACE 3 provide?

Answer 2

• The ACE‐III provides an overall measure of cognitive ability, as well as performance across five cognitive subdomains: attention and orientation, memory, verbal fluency, language and visuospatial ability
• the ACE‐III is sensitive to cognitive changes across a wide spectrum of severity levels, from mild cognitive impairment to severe dementia making it useful for tracking cognitive decline in these populations

Question 3

ACE 3 comparison with other screening tools

Answer 3

The ACE‐III has been shown to outperform other brief screening measures, such as the MMSE and the Montreal Cognitive Assessment, making it particularly useful for providing an overview of a person’s overall cognitive functioning when comprehensive neuropsychological testing is not feasible

Question 4

Benefits of using cognitive assessments

Answer 4

• Standardised stratification of cognitive performance into delineated bands can help clinicians and researchers detect when a cognitive change crosses a meaningful threshold, either due to disease progression or as an effect of treatment.
• Such metrics can also assist in the challenging process of accurately characterising cognitive components of disease staging within clinical research studies.
• It can also assist in enabling thorough monitoring of prognosis and selection of suitable treatment options within public health settings

Question 5

What is ACE 3 scored out of?

Answer 5

100 maximum points

Question 6

What are variables that affect interpretation of the cut-off points

Answer 6

• Years of education
• Age (older score less)
• Premorbid IQ
• Translation of different languages

Question 7

What is an alternative to ACE 3?

Answer 7

Mini-ACE

Question 8

What is Mini-ACE?

Answer 8

a shorter version of the ACE-III, and it was developed for use in settings where administration of the full ACE-III is not practical

Question 9

Total score of M-ACE and time it takes to perform

Answer 9

30
5 minutes

Question 10

Cut offs for ACE 3 in suspicion of dementia and sensitivity/specifity

Answer 10

88/100 Sensitivity of 100% and specificity of 96%

Question 11

Cut offs for M-ACE