1
Q
Acetaminophen
A
Analgesic
Antipyretic
Little to no anti-inflammatory effects
No anti-platelet effects.
2
Q
Acetaminophen Mechanism of Action
A
Inhibits COX. But only a COX present in CNS
No peripheral therapeutic sites of action
3
Q
Antipyretic
A
Reduce fever
Inhibit prostaglandin E2 production within hypothalamus
4
Q
Acetaminophen max daily dose
A
4000mg/day for adult
2400mg/day age 11-12
5
Q
Acetaminophen Contraindications
A
hepatic disease
renal disease
alcoholism
drug allergy
6
Q
Acetaminophen toxicity
A
OD: Hepatic necrosis (drug-induced hepatitis)
Can be lethal
Long-term ingestion of large doses can cause nephropathy
7
Q
Acetaminophen overdose antidote
A
Acetylcysteine (mucomyst)
Protects liver from acetaminophen-induced damage
