Ach synthesized by
choline and acetyl CoA
Ach catalyzed by
ChAT
Ach loaded into vesicles by
VACHT
vesamicol
blocks VACHT
botulism
prevents fusion of synaptic vesicles with terminal membrane
Ach broken down by
AchE
Ach broken down to
choline and acetic acid
forms of AchE
soluble, G4 tethered, A12
AchE reversible inhibitors treat
dementia, glaucoma
irreversible AchE inhibitors
organophosphorus compounds
LDTg and PPTg roles
drug reward and reinforcement and REM
nicotinic receptors
inotropic,
muscarinic receptors
metabotropic, used to treat psych disorders, cause dry mouth