Acne Flashcards

Question

therapeutic algorithm for mild acne

Answer 1

mild = comedones, few papules and pustules 1. treat w/ benzoyl peroxide or topical retinoid or topical combo therapy 2. if benzoyl peroxide or topical retinoid if not on already, swtich to diff topical combo therapy, or consider alternative topicals (dapsone or azelaic acid) if none owrk move to moderate recs

Answer 2

moderate = several pustules an dpapules, possible a few nodules 1. topical therapy and oral antibiotic OR topical therapy and COC or spironolactone (females) 2. switch to diff topical therapy or add oral antibiotic or add COC or spionolactone if doest work do severe

Answer 3

severe acne = numerous paples, pustules, multiple nodules, cysts, scarring 1. oral isotretinoin or topical therapy and oral antibiotic or topical therapy and COC (or) spironolactone for females 2. switch to diff topical, or add COC or oral spironolactione, or stop oral antibiotics and topical therapy and start oral isotretinoin or stop iso tretinoin and change to oral antibioic & topical therapy &/or COC or oral spironolacone

Answer 4

1. Benzoyl Peroxide (BPO) 2. Salicylic Acid 3. Azelaic acid 4. Dapsone 5. Topical Retinoids 6. Topical Antibiotics 7. Oral Antibiotics 8. Anti-androgen/OCP 9. orl retinoids

Answer 5

* when to use * 1st line for mild/mod comedonal acne * MOA * antibacterial (oxidation of bacterial proteins, eliminates C.acnes on surface of skin and sebacious follicles * keratolytic and antiinflammatory * good at preventing bactieral resistance so ocmbined w/ antibiotics * strength * 2.5% most common -\> some evidence suggests taht higher strength not more effective * scheuldes wehn \>5% or in combo w/ topical antibiotic or retinoid * vehicles * gel, cream, solution, lotion, wash soap * dont rec soap bc little contact with skin * response time * fast onset of action (within week but optimal in 8-12)

Answer 6

* directions * apply topically to entire affected area * to minimize irritation: app 15 min on 1st night, then 30 min on 2nd, eventually increase to overnight * adverse * dryness, peeling, irritation, bleaches clothing, smell that lingers (body odor) * contact dermatitis possible * Additional notes * 30 SPF uring day, BP apply at night * clinical worsening for first 2-4 weeks possible * can stain lcothes -\> use at night * can be used in preg and breast feeding * Always added to oral OR topical antibiotic regimen to decrease resistance to ABX

Answer 7

* when to use * avail as non Rx for comedonal acne * MOA * Mildly comedolytic,keratolytic, mildly antibacterial, mildly anti-inflammatory * strength * 0.5-3.5% BID (strengths under 20% are unschedules) * vehicles * gels, toners, cleansers, washes, pads * response time * variable, optimal ipmorvement in 8-12 w * directions for use * most BID but checl product * adverse * burning, stinging, drying

Answer 8

* when to use * prescription product for comedonal acne * helps reduce hyperpigmentation * less irritation then BPO but less efficacy * MOA * comedolyic and antibactieral but does not promote resistance orgnaisms * strength/vehicle * 15% gel * response time * 8-12 w * directions * BID * adverse * well tolerated * notes * can be used during pregnancy

Answer 9

* when to use * prescritpion topical product to terat inflammatory acne * MOA * synthetic sulfone that is antiinflammatory and antibacterial * Cannot use orally due to side effects * strength/vehicle * 5% gel * response time * 8-12 weels * directions * BIG * adverse * midly irrittating, may discolour skin * notes * safey in pregnancy not established

Answer 10

* when to use * can be used as first line for all types of acne in monotherapy or combination * MOA * dec inflammatory and non inflammatroy lesions * normalizes follicular desquamation * rach retinoid binds diff set or retinoic acid receptors, so each has slightly diff activity, tolerability and efficacy * strength/vehicle * all schedule 1 as single entity or combo * avail as gel or cream * response time * max response in 12w, acne will worsen during first few weeks * directions * apply pea sized amount to enitre affected area (not on damp skin) * to minimize irritation, start applying 12 min 1st night, 30 2nd etc * use at night due to sen sensivityity *

Answer 11

* adverse * irritation, burning, hypopigmentation, photosensitivity * start slow go slow * Additional notes * need sunscren SPF 30 during say * discontinue 1 week b4 sunny vacation or dermal procedure * adapelene and retin-a micro are better tolerated * helpful to address scarring and hyperpigmentation * do NOT use on atopic dermatitis * odo NOT use in pregnngacy (esp if applcition \>20% BSA) * good for anti aging * Examples * adapalene, tazarotene, trifarotene, and tretinoin

Answer 12

* when to use * prescription product for inflammatroy acne * MOA * dec skin colonization of C. acnes and decreases inflammation * strength.vehicle * 1% topical solution or pads * response time * 8-12 weks * directiosn for use * BID, must use with BPO * Adverse effects * CI in history of colitis! \*\*only in clindamycin * midly irritating, peeling, itching, dryness * Additional notes * can be used in pregnancy

Answer 13

* Antibiotic + retinoids * Biacna Gel (clindamycin 1.2% + tretinoin 0.025%) * Stievamycin Gel (0.01-0.05% tretinoin + 4% erythromycin) * Benzoyl peroxide + retinoid * Tacupump gel (adapalene 0.1%+ BP 2.5%) * Tactupump FORTE gel (adapalene 0.3% +BP 2.5%) * Benzoyl peroxide + antibiotics * BenzaClin, Clindoxyl (benzoyl peroxide 5% + clindamycin 1%) * Benzamycin (benzoyl peroxide 5% + erythromycin 3%)

Acne Flashcards

(38 cards)