What are the main phases of the cardiac action potential?
Phase 0 (depolarisation), phase 1 (initial repolarisation), phase 2 (plateau), phase 3 (repolarisation), phase 4 (resting potential).
Which ions are involved in phase 0 depolarisation in atrial/ventricular cells?
Rapid sodium influx through voltage-gated sodium channels.
What causes the plateau phase (phase 2)?
Balance between calcium influx and potassium efflux.
Why is the plateau phase important?
It prolongs contraction and prevents tetany of the heart.
What determines automaticity in pacemaker cells?
Gradual depolarisation during phase 4 driven by funny (If) channels.