Adaptive Immune Response

Question 1

What are the cells of adaptive immunity?

Answer 1

B and T cells

Question 2

Which cell line gives rise to humoral immunity?

Answer 2

B cells, which produce immunoglobins

Question 3

Which cells give rise to cellular immunity?

Answer 3

T cells

Question 4

What do Abs do?

Answer 4

Recognize foreign ags, neutralize the infectivity, and target them for elimination by effector cells

Question 6

What is the prinicipal defense mechanism against extracellular microbes?

Answer 6

Humoral adaptive immunity- because the secreted Abs can bind to the Ags and toxins to assist in elimination

Question 7

What mediates intracellular immunity?

Answer 7

Cell Mediated Adaptive Immunity

(CMI)

Question 8

What is the function of CMI?

Answer 8

To destroy the infected host cells through apoptosis. Getting rid of the reservoirs of infection.

Question 9

What cells help B cells produce Abs?

Answer 9

Helper T cells

Question 10

What two things can T Helper cells do in CMI?

Answer 10

1. Activate macrophages to kill phagocytized microbes
2. Become cytotoxic T lymphocytes (CTL) to destroy infected cells directly

Question 11

What did Paul Ehrlich do?

Answer 11

• Said that immune cells can secrete receptors (Ags) that recognize microbes.
• Coined tern Antibody
• His emphasis on Ab lead to acceptance of humoral theory of immunity- the defense mechanisms are in our blood

Question 12

What did Elie Metchnikoff do?

Answer 12

• FOunder of cellular theory of immunity
• discovered phagocytes which he said were principal effector mechanism of immunity
• Shared Nobel with Ehrlich for Fundamental Principles of Immunity