adaptive immunity

Question 1

Outline the subset of lymphocytes

Answer 1

multipotent stem cell–>lymphoid progenitor—-> B lymphocytes—> plasma cell

• –> T lymphocytes
• –> NK cell

Question 2

summarise the common stages of B and T cell development

Answer 2

1st stage: generation of and antigen receptor via VDJ gene rearrangement

2nd stage: refinement of antigen receptor repertoire via +ve selection, those that bind not too strongly and not too weakly

3rd stage: stim by foreign antigen, clonal selection of lymphocytes, generation of effector and memory lymphocytes