Alkylating Agents

Question 1

Alkylating Agents prototype

Answer 1

Chlorambucil

Question 2

Chlorambucil indications

Answer 2

Palliative treatment of chronic lymphocytic leukemia, malignant lymphomas, and Hodgkin disease.

Question 3

Chlorambucil actions

Answer 3

Alkylates cellular DNA, interfering with the replication of susceptible cells.

Question 4

Chlorambucil route, onset, peak, duration

Answer 4

Oral, varies, 1 h, 15-20 h

Question 5

Chlorambucil adverse effects

Answer 5

Tremors, muscle twitching, confusion, nausea, hepatotoxicity, bone marrow suppression, sterility, cancer.