What is the cut off time for drug timeline in SCAR (severe cutaneous adverse reaction)?
8 weeks! Any drug pt has been on for 8 weeks or longer cannot be the culprit
What should you refer SCAR patients for?
Skin testing (some time after the acute incident has resolved)
Cause of erythema multi forms?
Never a drug
Causes by infection or other
Look hard for HSV
What are the most common drugs causing SCAR?
Vanc, piptaz and Bactrim
Acute renal failure, fever and urinary eosinophils after a drug?
AIN!
Acute Cross reactivity rate between cephalosporins and penicillins
<2%
Does not apply to delayed reactions eg DRESS