Amiodarone

Question 1

Amiodarone Class

Answer 1

Antydysrhythmic

Question 2

Amiodarone Mechanism of Action

Answer 2

• Blocks sodium, potassium, and calcium channels
• Prolongs the action potential’s duration
• Delays repolarization
• Decreases AV conduction and sinoatrial (SA) node function

Question 3

Amiodarone Indications

Answer 3

• Cardiac arrest resulting from VF pulseless VT after CPR, defibrillation, and epinephrine
• Stable, regular narrow-complex tachycardia if the rhythm persists despite vagal maneuvers or adenosine or the tachycardia is recurrent
• To control the ventricular rate in AF with a rapid ventricular response without preexcitation

Question 4

Amiodarone Contraindications

Answer 4

Iodine hypersensitivity, Cardiogenic shock, Second or third degree AV block

Question 5

Amiodarone Dosage and Administration

Answer 5

• Initial dose: 300 mg IV/IO
• Second dose: 150 mg IV/IO
• Loading dose: 150 mg IV/IO over 10 min
  After conversion, follow with an infusion of: 10 - 50 mg/h over 24 hours
• Max cumulative dose: 2.2 g IV/IO per 24 hours