Amiodarone

Question 1

Amiodarone: Full name

Answer 1

Amiodarone Hydrochloride

Question 2

Amiodarone: Trade names

Answer 2

• Coradarone
• Pacerone
• Nexterone

Question 3

Amiodarone: Class

Answer 3

Antiarrhythmic

Question 4

Amiodarone: Action

Answer 4

• blocks sodium, potassium, and calcium channels in cardiac cells
  Slows conduction and prolongs repolarization
• Has alpha and beta adrenergic blocking properties, causing negative inotropic effects and reduces peripheral vascular resistance (AFTERLOAD)

Question 5

Amiodarone: Onset/Duration

Answer 5

Onset: minutes

Duration: days

Question 6

Amiodarone: Indications

Answer 6

• Stable VT
• Reported/witnessed ≥ AICD firing
  OR ≥ 1 AED shock delivered with pulses ≥ 60
• VF/pulseless VT: After 1st shock if still refractory

Question 7

Amiodarone: Dosage/Route for stable VT

Answer 7

ADULT only (SO):
- 150mg in 100ml of NS over 10” IV/IO (piggyback)

MR x1 in 10” (SO)

Question 8

Amiodarone:
Dosage/Route
- for ≥ AICD firing or ≥ 1 AED shock (with pulse ≥ 60)

Answer 8

Adult Only, (SO):

- 150mg in 100ml of NS over 10” IV/IO piggyback… SO

Question 9

Amiodarone:
Dosage/Route
- for VF/pulseless VT

Answer 9

Adult:
300mg IV/IO SO; MR 150mg (max 450mg) .. SO

PEDS:
PDC IV/IO (SO) MR x1 in 3-5” SO

Question 10

Amiodarone: Contraindications

Answer 10

• hypotension
• 2nd and 3rd degree heart block
• Idioventricular rhythms

Question 11

Amiodarone: Side effects

Answer 11

• Hypotension
• Exacerbation of presenting arrhythmia
• Liver injury
• Pulmonary injury, pulmonary infiltrates, bronchospasm, SOB cough hemoptysis, hypoxia

Question 12

Amiodarone: Packaging

Answer 12

150mg / 3 ml

Question 13

Amiodarone: Administration

Answer 13

Piggyback infusion in 100ml of NS over 10 minutes

- drip rate with 60ggts/ml tubing = 10 gtts/second