What is amitriptyline?
Migraine: increase serotonin to change how nerves perceive pain. Prevents migraines, not treat
How is amitriptyline taken?
OD at night, takes 4-6 weeks of use to feel full benefit. Do not stop abruptly, wean off
Monitoring of amitriptyline?
None
Side effects of amitriptyline?
Weight gain, tiredness, constipation, drowsiness, blurry vision and dry mouth
Pregnancy (amitriptyline)
No known complications
Contraindications of amitriptyline?
Arrthymia/heart block, severe hepatic impairment, manic bipolar
ECG changes of amitriptyline overdose?
Sinus tachy, wide QRS, prolonged QT