what are methods of analysis of pharmaceutical products?
- UV/Vis spectrophotometry
- high pressure liquid chromotography
what are methods of analysis of solid product?
infrared spectroscopy
x-ray diffraction
what is the increasing energy of molecular absorption spectra?
Rotational - dipoles rotate absorbing energy
Vibrational - bonds absorb energy and vibrate
Electronic - molecules changes electronic configulration
what does spectrum of UV/visible show
broad bands rather than sharp lines
at room temperature what state are molecules in?
vibrational and electronic states
what is the beer lambert law?
the intensity of a beam of parallel monochromatic light decreases exponentially with the number of absorbing molecules
what is A in the beer lambert law?
the absorbance of a 1g/100ml solution in 1cm cell at specific wavelength
what is required for light scattering?
a filter
what are errors of light scattering
increase at shorter wavelengths
what is the physiological properties of the solid dosage forms correlated with?
crystal structure of raw materials
what is the theory of IR absorption?
- IR has less energy than UV/vis
- absorption causes vibrational and rotational energy levels
- absorption of IR must caude a change in the dipole moment of the molecule
what is polymorphism?
ability of a compound to crystalline in more than one 3D packing arrangment
what forms show diffraction in x-ray?
crystlline does
amorphous doesnt
