Anaphylaxis

Question 1

what is anaphylaxis?

Answer 1

severe type 1 hypersensitivity reaction. IgE stimulates mast cells to release histamine and other pro-inflammatory chemicals.

Question 2

presentation of anaphylaxis?

Answer 2

urticaria, itching, angio-oedema, abdominal pain, sob, wheeze, swelling of larynx causing stridor, tachycardia, lightheadedness, collapse

Question 3

medication for anaphylaxis?

Answer 3

IM adrenalin- repeated after 5 mins if needed
antihistamines- oral chlorphenamine or cetirizine
steroids- IV hydrocortisone

Question 4

how can anaphylaxis be confirmed?

Answer 4

measuring mast cell tryptase within 6 hours