Andersen: Junctions

Question 1

Binding between cadherins is generally

Answer 1

Homophillic

Question 2

Calcium role in cadherins

Answer 2

Calcium ions bind to hinge sites connecting cadherin domains in extracellular surface. This strengthens the site and keeps it from bending. When calcium is removed, the cadherin structure becomes floppy and degrades

Question 3

Cadherin and cell sorting

Answer 3

Cadherin-dependent homophilic interactions mediate highly selective recognition, enabling cells of a similar type to stick together and stay segregated from other cell types

Question 4

Catenins

Answer 4

Small proteins that link cytoplasmic end of cadherin with cytoplasmic actin

Question 5

Conserved polarity proteins

Answer 5

Par
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