Anemia

Question 1

[Hematopoeitic Growth Factor]

What are the parenteral forms of iron

Answer 1

1. Iron dextran
2. Na ferric gluconate complex
3. Iron sucrose

Question 2

[Diagnosis]

necrotizing gastoenteritis, shock, metabolic acidosis

Answer 2

Acute iron intoxication

Question 3

[Diagnosis]

Cirrhosis, DM, skin pigmentation

Answer 3

Hemochromatosis

Question 4

What are the examples if iron chelators?

Answer 4

1. Deferoxamine
2. Deferasirox
3. Deferiprone

Question 5

What is the drug of choice for acute iron intoxication

Answer 5

Deferoxamine IV

Question 6

What is the drug of choice for chronic iron intoxication?

Answer 6

Deferasirox PO

Deferiprone PO

Question 7

Vitamin B12 is a cofactor in _____

Answer 7

transfer of 1 carbon units

Question 8

What are the 2 essential reaction in which vitamin B 12 plays a role?

Answer 8

1. Conversion of methylmalonyl-CoA to succinyl-CoA

2. Conversion of homcystein to methionine

Question 9

Vitamin B 12 deficiency leads to the accumulation of what compound?

Answer 9

N5-methyltetrahydrofolate

Question 10

What is the storage life of cyanocobalamin in the liver?

Answer 10

5 years

Question 11

What process does dihydropteroate synthase act on?

Answer 11

p-Aminobenzoic Acid to dihydrofolic acid

Question 12

Dihydrofolate reductase is essential in what reaction?

Answer 12

Dihydrofolic acid to tetrahydrofoloc acid

Question 13

Folic is absorbed in which part of the small intestine?

Answer 13

proximal jejunum