Anemia aplastica Flashcards by Lucia Fleser

Factori etio

b genetica
subst ch mielosupresive/toxice
radiatii
infectii
b clonale

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Patogenie

anomalii cant - depletie CS
anomalii calit - scaderea capacit de autoreinnoire, perturb ech autoreinnoire-dif
supresie imuna umorala/cel/citokine
anomalii micromediu
deficit fact de crestere hematopoietici

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Hlg

PANCITOPENIE
anemie normo/normo, ret scazute
leucopenie, granulopenie
trombocitopenie

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Medulograma

saraca
serii mieloife diminuate/absente
infiltrat Ly, Pl, Mfg

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BOM

hipocel
insule rest de hematopoieza
exsudat fibros, fb retic ingros
infiltrat Ly, Pl, Mfg

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Severitate medie

G <1000
PLT <50.000
Ret < 60.000
Hb < 10 g/dl

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AA severa

G <500
PLT < 20.000
ret < 10.000
MO aplazica

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AA f severa

G < 200 (agranulocitoza)

PLT < 20.000

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Tratament AA medie

imunosupresie, androgeni, f crest hematopoietici

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Tratament AA severa si f severa

transplant medular + imunosupresie

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Anemia aplastica Flashcards

(10 cards)