Midazolam T1/2
1.5-3 hrs
Fentanyl T1/2
2-4 hrs
Propofol T1/2
0.5-1.5 hrs
Ketamine T1/2
2-3 hrs
Precedex T1/2
2 hrs
Flumazenil T1/2
0.7-1.3 hrs
Naloxone T1/2
0.5-1.5 hrs
Midazolam dosage
0.02-0.1 mg/kg (< 5mg)
Fentanyl dosage
1-2 mcg/kg (< 200 mcg)
Propofol dosage (conservative)
0.5 mg/kg
(0.5-1.5 mg/kg bolus; 75 mcg/kg infusion)
Ketamine dosage
0.5-1.0 mg/kg bolus; 0.1-0.5 mg/kg/hr infusion
Precedex dosage
0.5-1.0 mcg/kg (slow administration over 10-20 minutes)
0.2-0.7 mcg/kg/hr infusion
___ is also an analgesic
Ketamine
___ increases secretions
Ketamine
___ burns on injection
Propofol
Precedex negatives
Bradycardia and hypotension
Precedex positives
Minimal respiratory depression
Flumazenil dosage
0.2 mg q1min (3 mg max)
Naloxone dosage
0.4 mg q2-3 min
How to treat chest wall rigidity?
NM blocker or
Deepen sedation with propofol + PPV
How long must you monitor patient if flumazenil or naloxone was used?
2 hrs
3 causes of hypoxia during sedation
obstruction
hypoventilation (oversedation) = PPV
bronchospasm/laryngospasm
How to treat hypotension?
Stop propofol
trendelenburg
fluids
ephedrine/phenylephrine
Succinylcholine dosage
0.5-1.0 mg/kg