Angina pectoris
Chest pain / discomfort caused by myocardial ischemia
Mismatch O2 supply and Demand
Infaction
NO O2
Ischemia
ππ»O2
Disease
Coronary artery disease
Pathophysiology
Atherosclerosis
Build up clot
Manifestation of Coronary Artery disease
Acute manifestation CAD
-Acute coronary syndrome
Types of acute coronary syndrome
Acute MI -STEMI =occlusive -NSTEMI=non occlusive Unstable Angina Pectoris -Rest Angina -crescendo -new onset
Acute MI
βπ»οΈcardiac biomarkers
Troponin
CK
Unstable Angina Pectoris
(-)Cardiac Biomarkers
STEMI? And indicate the drugs
Completely block
NSTEMI? And what drugs
Partially block
Anticoagulants
Chronic stable angina pectoris
βπ»οΈ O2 _____?
βπ»οΈO2 demand
Vasopasm
Prinzmetal angina
Aprroach to managemt
βπ»οΈO2 supply
ππ»O2 demand
Give mngt in βπ»οΈO2 supply
Give the mngt in ππ»O2 demand
What happen if the O2 demand ππ»
ππ»HR
ππ»SV
ππ»SVR
What is the MOA of nitrovasodilators
βπ»οΈNO but requires SH group
What are the effects that may occur in nitrovasodilators having a Low dose
Peripheral venodilation
ππ»preload
ππ»O2 demand
What are the effects that may occur in nitrovasodilators having a High dose
Arteriolar vasodilation
βπ»οΈO2 supply
What is the SE in high dose nitrovasodilators
Reflex tachycardia
βπ»οΈO2 demand
What is the remedy in high dose in nitrovasodilators
Beta blockers
Drugs in nitrovasodilators
Very short acting
Short acting
Intermediate acting
Long acting agents